The analgesic efficacy of intra-articular acetaminophen in an experimental model of carrageenan-induced arthritis

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dc.contributor.authorArun, Oguzhan
dc.contributor.authorCanbay, Ozgur
dc.contributor.authorCelebi, Nalan
dc.contributor.authorSahin, Altan
dc.contributor.authorKonan, Ali
dc.contributor.authorAtilla, Pergin
dc.contributor.authorAypar, Ulku
dc.date.accessioned2020-03-26T18:43:47Z
dc.date.available2020-03-26T18:43:47Z
dc.date.issued2013
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBACKGROUND: Acetaminophen is one of the most common drugs used for the treatment of pain and fever. OBJECTIVES: To examine the effects of intra-articular (IA) acetaminophen on carrageenan-induced arthritic pain-related behaviour and spinal c-Fos expression in rats. METHODS: The present study was performed using 20 Sprague Dawley rats. Forty microlitres of IA 0.9% NaCl was injected in the control group, and 40 mu L of IA carrageenan was injected in the carrageenan group. One hour after carrageenan injection, 400 mu g of IA acetaminophen was injected in the IA acetaminophen group, and 400 mu g of intraperitoneal (IP) acetaminophen was injected in the IP acetaminophen group. One day before injection, and 4 h and 8 h after injection, diameters of both knee joints, motility of the rat, paw loading and joint mobility were assessed. After the rats were euthanized, L3 and L4 spinal segments were excised for c-Fos assessment. RESULTS: IA acetaminophen decreased both the severity and distribution of c-Fos expression. IP acetaminophen decreased only the distribution of c-Fos expression. IA acetaminophen decreased knee diameter at 8 h. IA and IP acetaminophen increased rat motility and paw loading scores. Joint mobility scores of IP acetaminophen were similar to saline at 8 h. CONCLUSIONS: Results of the present study indicate an analgesic and/or possible anti-inflammatory effect of IA acetaminophen and provide further evidence on the efficacy of systemic acetaminophen injection in reducing arthritic pain.en_US
dc.identifier.doi10.1155/2013/148392en_US
dc.identifier.endpageE67en_US
dc.identifier.issn1203-6765en_US
dc.identifier.issn1918-1523en_US
dc.identifier.issue5en_US
dc.identifier.pmid24093120en_US
dc.identifier.startpageE63en_US
dc.identifier.urihttps://dx.doi.org/10.1155/2013/148392
dc.identifier.urihttps://hdl.handle.net/20.500.12395/29889
dc.identifier.volume18en_US
dc.identifier.wosWOS:000328154700001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHINDAWI LTDen_US
dc.relation.ispartofPAIN RESEARCH & MANAGEMENTen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectArthritic painen_US
dc.subjectCarrageenanen_US
dc.subjectc-Fosen_US
dc.subjectIntra-articular acetaminophenen_US
dc.titleThe analgesic efficacy of intra-articular acetaminophen in an experimental model of carrageenan-induced arthritisen_US
dc.typeArticleen_US

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