Surrogate testes: Allogeneic spermatogonial stem cell transplantation within an encapsulation device may restore male fertility

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dc.contributor.authorGül M.
dc.contributor.authorDong L.
dc.contributor.authorWang D.
dc.contributor.authorDiri M.A.
dc.contributor.authorAndersen C.Y.
dc.date.accessioned2020-03-26T20:20:56Z
dc.date.available2020-03-26T20:20:56Z
dc.date.issued2020
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractToxic insult to the gonads by chemotherapy or radiotherapy can lead to permanent infertility. It's an important health concern because each year more than 4000 male patients are at risk of azoospermia in the United States due to gonadotoxicity of the regimens used. There are also several benign/genetic diseases whose natural course can result in infertility without gonadotoxic therapy. Considering the fact that most of these people are cured and survive with the advent of modern medicine, infertility is related to serious psychological and relationship implications and parenthood is a significant issue for those patients. Semen cryopreservation option is available for postpubertal adolescent and adult men, while children do not have this storing option since they do not have mature spermatozoa. However, their testes contain spermatogonial stem cells (SSCs), which are initiators of spermatogenesis. Promising findings in animal studies and human cell lines have encouraged scientists that SSCs may be hope for restoring fertility option of patients who cannot produce functional sperm and who have no other choice to preserve their future fertility. For this reason, several centers around the world already began to collect and cryopreserve testicular tissue or cells with anticipation that SSC-based therapies will be available in the near future; however, an optimal transplantation design in humans is yet to be developed. Here we propose an allogeneic testicular stem cell transplantation with an encapsulation device to restore fertility in patients with infertility. We endeavor to discuss the reliability of this method with the current literature and bring the evidence on its feasibility © 2020 Elsevier Ltden_US
dc.description.sponsorshipDr. Murat Gul is supported by the European Urological Scholarship Programs ( EUSP ) for his post-doctoral andrology fellowship training.en_US
dc.identifier.doi10.1016/j.mehy.2020.109634en_US
dc.identifier.issn0306-9877en_US
dc.identifier.pmid32087491en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.mehy.2020.109634
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38703
dc.identifier.volume139en_US
dc.identifier.wosWOS:000531083000019en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherChurchill Livingstoneen_US
dc.relation.ispartofMedical Hypothesesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleSurrogate testes: Allogeneic spermatogonial stem cell transplantation within an encapsulation device may restore male fertilityen_US
dc.typeArticleen_US

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