The Effect of Cigarette Smoke in Bleomicyn Induced Pulmonary Fibrosis in the Rat Model

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dc.contributor.authorMaden, Emin
dc.contributor.authorToy, Hatice
dc.contributor.authorTeke, Turgut
dc.contributor.authorKorkmaz, Celalettin
dc.contributor.authorKiyici, Halil
dc.contributor.authorImecik, Oktay
dc.contributor.authorGok, Mehmet
dc.date.accessioned2020-03-26T18:16:36Z
dc.date.available2020-03-26T18:16:36Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe role of cigarette smoking in the development and outcome of pulmonary fibrosis is uncertain. In this study, we aimed to assess the effect of route of bleomycin exposure in the development of pulmonary fibrosis and the effects of cigarette smoke on bleomycin-induced lung fibrosis. We studied five groups of rats; 1-control group, 2-intratracheal bleomycin (IT), 3- intratracheal bleomycin plus cigarette smoke for 4 wk (IT-S), 4- inhaled bleomycin (IN), 5- inhaled bleomycin plus cigarette smoke for 4 wk (IN-S). According to Aschoft's criteria, fibrosis score was higher in IT and IT-S compared to control, IN and INS groups. There was no significant difference between IT and IT-S groups. Histopathological evaluation of the lungs of rats revealed that neutrophils, macrophages, plasma cells and lymphocytes in alveolar interstitial space were significantly higher in IT and IT-S compared to IN and IN-S (p < 0.001). IT and IT-S showed a severe collagen, laminin, elastin, fibronectin and proteoglican levels in alveolar, vascular, airway and interstitial space. IN and IN-S showed mild inflammation in lung. There were alveolitis, edema, peribronchial fibrosis, fibroblast proliferation and emphysematous lesions in all groups except for the control group. In this study, we showed that in the development of pulmonary fibrosis in rats, intratracheal administration of bleomycin is more effective than bleomycin inhalation and smoking has no additional effect on development of fibrosis.en_US
dc.identifier.doi10.4999/uhod.10042en_US
dc.identifier.endpage146en_US
dc.identifier.issn1306-133Xen_US
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage141en_US
dc.identifier.urihttps://dx.doi.org/10.4999/uhod.10042
dc.identifier.urihttps://hdl.handle.net/20.500.12395/26898
dc.identifier.volume21en_US
dc.identifier.wosWOS:000295573200002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherAKAD DOKTORLAR YAYINEVIen_US
dc.relation.ispartofUHOD-ULUSLARARASI HEMATOLOJI-ONKOLOJI DERGISIen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectBleomycinen_US
dc.subjectPulmonary fibrosisen_US
dc.subjectCigarette smokingen_US
dc.titleThe Effect of Cigarette Smoke in Bleomicyn Induced Pulmonary Fibrosis in the Rat Modelen_US
dc.typeArticleen_US

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