COMPARISION OF VACUUM-ASISTED CLOSURE AND INTRALESIONAL EPIDERMAL GROWTH FACTOR IN THE TREATMENT OF DIABETIC FOOT WOUNDS PATIENTS

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dc.contributor.authorÇolak, Bayram
dc.contributor.authorKirazlı, Halil
dc.contributor.authorEce, İlhan
dc.contributor.authorYormaz, Serdar
dc.contributor.authorŞahin, Mustafa
dc.date.accessioned2020-03-26T19:53:09Z
dc.date.available2020-03-26T19:53:09Z
dc.date.issued2018
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIntroduction: Diabetes mellitus (DM) is a common public health problem all over the world with serious complications. The mortality rate is 40% within 5 years in patients with major amputation due to diabetic foot wounds (DFW). Therefore, a nonsurgical but effective treatment method is needed for the treatment of DFW. In this study, we aimed to compare the results of intralesional epidermal growth factor (EGF) injection and negative pressure wound therapy (NPWT) for the treatment of DFW. Materials and methods: The medical records of patients who were treated for DFW with EGF or NPWT between February 2017 and December 2017 were retrospectively reviewed. Patients demographics, wound characteristics, allergic reactions and treatment responses were evaluated. Results: Amongst 42 patients, 20 patients were treated with the injection of EGF and 22 patients treated with NPWT. The duration of diabetes was higher in EGF group when compared to the NPWT group without a statistically significance (EGF: 20,7 years, NPWT: 16,9 years). According to the Wagner-Meggitt classification, the grade of the wounds was comparable in both groups. A complete response were obtained in 17 (85%) patients and 50% wound closure was achieved in the other patients in EGF group. In the NPWT group complete response rate was 45.4%. No major amputation was performed in any patient. In NPWT group, 13 (59%) of wouds were closed with split-thickness skin graft, only 3 patients (15%) of the EGF group were required a skin graft. The main advers affect of the EGF injection was an elevated fasting blood glucose level. In both groups, A decreased HbA1c levels were found after the wound treatment. Conclusion: Both administration of intralesional EGF and NPWT are safe, effective and non-surgical methods for the treatment of DFW. NPWT is seems to be a more effective treatment modality for infected wounds.en_US
dc.identifier.doi10.19193/0393-6384_2018_5_191en_US
dc.identifier.endpage1252en_US
dc.identifier.issn0393-6384en_US
dc.identifier.issn2283-9720en_US
dc.identifier.issue5en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1245en_US
dc.identifier.urihttps://dx.doi.org/10.19193/0393-6384_2018_5_191
dc.identifier.urihttps://hdl.handle.net/20.500.12395/36419
dc.identifier.volume34en_US
dc.identifier.wosWOS:000437030700013en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherCARBONE EDITOREen_US
dc.relation.ispartofACTA MEDICA MEDITERRANEAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectGrowth factoren_US
dc.subjectdiabetic footen_US
dc.subjectnegative pressureen_US
dc.subjectwounden_US
dc.titleCOMPARISION OF VACUUM-ASISTED CLOSURE AND INTRALESIONAL EPIDERMAL GROWTH FACTOR IN THE TREATMENT OF DIABETIC FOOT WOUNDS PATIENTSen_US
dc.typeArticleen_US

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