Optimization of the extraction process of antioxidants from loquat leaves using response surface methodology

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dc.contributor.authorUysal, Şengül
dc.contributor.authorCvetanovic, Aleksandra
dc.contributor.authorZengin, Gökhan
dc.contributor.authorDurovic, Sasa
dc.contributor.authorAktümsek, Abdurrahman
dc.date.accessioned2020-03-26T19:42:14Z
dc.date.available2020-03-26T19:42:14Z
dc.date.issued2017
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThis study is designed to optimize the extraction of polyphenolics and antioxidant potential of loquat leaves using response surface methodology (RSM). Three levels and three variables Box-Behnken experimental design in combination with RSM was applied. Independent variables were solvent concentration (10-90%), temperature (20-60 degrees C) and time (60-180 min), while investigated response was total phenolic content as well as antioxidant activity. The experimental results were fitted to a second-order quadratic polynomial model, and they showed a good fit to the proposed model. In order to assess model fitness and determine optimal conditions, for maximal phenolic content and antioxidant activity, analysis of variance was employed. Determined optimized conditions for maximizing yield of antioxidant compounds were within the experimental range: ethanol concentration of 88.4%, extraction temperature of 28 degrees C, extraction time of 70.8 min. Under these conditions, the predicted maximum values were TP-77.18 mg GAE/g, DPPH-80.42 mg TE/g, CUPRAC-308.87 mg TE/g and FRAP-164.12 mg TE/g. Practical applicationsPlant phenolics have remarkable biological activities including antioxidant, antimicrobial and anticancer. Therefore, their extraction techniques have gained more attention in recent years. This study was designed to detect optimal extraction conditions of independent factors (i.e. solvent concentration, temperature and time) in order to obtain the highest yields of phenolics from loquat leaves as well as antioxidant activity. This study could be valuable for designing new nutraceutical and functional food ingredients in terms of high recovery of phenolics from loquat leaves.en_US
dc.identifier.doi10.1111/jfpp.13185en_US
dc.identifier.issn0145-8892en_US
dc.identifier.issn1745-4549en_US
dc.identifier.issue5en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://dx.doi.org/10.1111/jfpp.13185
dc.identifier.urihttps://hdl.handle.net/20.500.12395/35352
dc.identifier.volume41en_US
dc.identifier.wosWOS:000412658000080en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofJOURNAL OF FOOD PROCESSING AND PRESERVATIONen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectloquaten_US
dc.subjectantioxidantsen_US
dc.subjectoptimizationen_US
dc.subjectresponse surface methodologyen_US
dc.subjectphenolicsen_US
dc.titleOptimization of the extraction process of antioxidants from loquat leaves using response surface methodologyen_US
dc.typeArticleen_US

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