The effect of hyaluronan combined with microfracture on the treatment of chondral defects: An experimental study in a rabbit model

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dc.contributor.authorTuncay, İbrahim
dc.contributor.authorErkoçak, Ömer Faruk
dc.contributor.authorAcar, Mehmet Ali
dc.contributor.authorToy, Hatice
dc.date.accessioned2020-03-26T18:48:19Z
dc.date.available2020-03-26T18:48:19Z
dc.date.issued2013
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBecause articular hyaline cartilage has low potential for regeneration, numerous methods and techniques have been proposed to induce the reparation process. Microfracture is a convenient procedure for this purpose. However, the quality of the new cartilage after microfracture is still not as proper as original. In this experimental study, we used microfracture in combination with intraarticular application of hyaluronan in rabbit knee articular defect. Bilateral knee arthrotomies, chondral defects, and microfracture were created on each intercondylar notch in thirty rabbits. Rabbits received intraarticular injections of hyaluronan once a week for 3 weeks in the right knee, started from 1 week after injury. The left knees, which served as controls, were injected with normal saline. Biopsy was taken from both knees at the 4th and 6th weeks. In comparison with the control group, after 6 weeks we observed a higher potential for healing in the experimental group, with thicker and more organized repair tissue filling the defect. The current study reveals that application of hyaluronan after the microfracture might be beneficial in inducing articular cartilage defect reparation. © 2012 Springer-Verlag.en_US
dc.identifier.doi10.1007/s00590-012-1080-2en_US
dc.identifier.endpage758en_US
dc.identifier.issn1633-8065en_US
dc.identifier.issue7en_US
dc.identifier.pmid23412212en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage753en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s00590-012-1080-2
dc.identifier.urihttps://hdl.handle.net/20.500.12395/30208
dc.identifier.volume23en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofEuropean Journal of Orthopaedic Surgery and Traumatologyen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCartilage defecten_US
dc.subjectHyaluronanen_US
dc.subjectMicrofractureen_US
dc.titleThe effect of hyaluronan combined with microfracture on the treatment of chondral defects: An experimental study in a rabbit modelen_US
dc.typeReviewen_US

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