Prophylactic ozone administration reduces renal ischemia-reperfusion injury in the rat

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dc.contributor.authorKal, Öznur
dc.contributor.authorAkıllıoğlu, İshak
dc.contributor.authorKal, Ali
dc.contributor.authorÇelik, Esin
dc.contributor.authorYılmaz, Mustafa
dc.contributor.authorÖnal, Merih
dc.contributor.authorÖnal, Özkan
dc.date.accessioned2020-03-26T19:25:49Z
dc.date.available2020-03-26T19:25:49Z
dc.date.issued2016
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: The objective of this study was to examine the role of ozone oxidative preconditioning after renal IR (ischemia reperfusion) injury. Methods: Twenty-eight Wistar rats were randomized into four groups: sham operated (S), IR, ozone (O), and O+IR. The S group was administered physiological saline (PS) intraperitoneally (i.p.) for seven days. The IR group was subjected to renal ischemia for 1 h by occlusion of the left renal artery and vein, followed by reperfusion for 2 h. The O group was administered ozone i.p. for seven days. In the O+IR group, ozone was administered i.p. for seven days before the IR procedure. IR injury (as in the IR group) was induced on the eight day. Laboratory analyses of renal tissue samples for superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and malondialdehyde (MDA) were performed. Results: The total oxidant score (TOS) and total antioxidant capacity (TAC) of the blood samples were also analyzed. The degree of renal injury was highest in the IR group. In the O+IR group, renal injury was decreased. The antioxidant parameters were increased in the O group. The oxidant parameters were highest in the IR group. Conclusion: Ozone preconditioning ameliorated renal IR injury, with a significant decrease observed in the renal IR injury score.en_US
dc.identifier.endpage13688en_US
dc.identifier.issn1940-5901en_US
dc.identifier.issue7en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage13677en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/33910
dc.identifier.volume9en_US
dc.identifier.wosWOS:000386428400154en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherE-CENTURY PUBLISHING CORPen_US
dc.relation.ispartofINTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectIschemia reperfusion injuryen_US
dc.subjectkidneyen_US
dc.subjectozoneen_US
dc.subjectapoptosisen_US
dc.titleProphylactic ozone administration reduces renal ischemia-reperfusion injury in the raten_US
dc.typeArticleen_US

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