Rapid, efficient, and green synthesis of coumarin derivatives via Knoevenagel condensation and investigating their biological effects

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dc.contributor.authorDinparast, Leila
dc.contributor.authorHemmati, Salar
dc.contributor.authorZengin, Gökhan
dc.contributor.authorAlizadeh, Ali Akbar
dc.contributor.authorBahadori, Mir Babak
dc.contributor.authorKafil, Hossein Samadi
dc.contributor.authorDastmalchi, Siavoush
dc.date.accessioned2020-03-26T20:19:12Z
dc.date.available2020-03-26T20:19:12Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Fen Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractCoumarins as naturally occurring heterocycles are chemically and biologically attractive compounds due to their diverse pharmacological properties. This study aimed to design a green method for the synthesis of coumarin derivatives followed by their biological investigations. To do so, coumarins were synthesized with excellent yields using a one-pot procedure under solvent-free conditions at room temperature with very short reaction times. 1-hexyl-3-methylimidazolium bromide was used as a reaction medium and an alternative for common toxic solvents. The structure of coumarins was confirmed using spectroscopic techniques as well as elemental analysis. The cytotoxicity of coumarins was evaluated against A549 cancerous cells and was found to be non-cytotoxic in nature. Also, their abilities for inhibition of acetylcholinesterase, tyrosinase, and alpha-glucosidase were assessed. The results showed that some derivatives have mild to moderate inhibitory activity (IC50=3.64-5.96 mm) against acetylcholinesterase. The tested coumarins have also moderately inhibited tyrosinase (IC50=3.95-13.96 mm). The results of this study could be useful for the design and development of green and effective methods for the synthesis of new drugs with the core structure of coumarin.en_US
dc.description.sponsorshipMinistry of Health and Medical Education; Biotechnology Research Center at Tabriz University of Medical Sciencesen_US
dc.description.sponsorshipThe authors would like to acknowledge the Ministry of Health and Medical Education, and also, Biotechnology Research Center at Tabriz University of Medical Sciences for the financial support.en_US
dc.identifier.citationDinparast, L., Hemmati, S., Zengin, G., Alizadeh, A. A., Bahadori, M. B., Kafil, H. S., Dastmalchi, S. (2019). Rapid, Efficient, and Green Synthesis of Coumarin Derivatives via Knoevenagel Condensation and Investigating Their Biological. Chemistry Select, 4(31), 9211-9215.
dc.identifier.doi10.1002/slct.201901921en_US
dc.identifier.endpage9215en_US
dc.identifier.issn2365-6549en_US
dc.identifier.issue31en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage9211en_US
dc.identifier.urihttps://dx.doi.org/10.1002/slct.201901921
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38149
dc.identifier.volume4en_US
dc.identifier.wosWOS:000482518400045en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorZengin, Gökhan
dc.language.isoenen_US
dc.publisherWILEY-V C H VERLAG GMBHen_US
dc.relation.ispartofCHEMISTRYSELECTen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectBiological activityen_US
dc.subjectCoumarinen_US
dc.subjectEnzyme inhibitionen_US
dc.subjectGreen chemistryen_US
dc.subjectIonic liquiden_US
dc.titleRapid, efficient, and green synthesis of coumarin derivatives via Knoevenagel condensation and investigating their biological effectsen_US
dc.typeArticleen_US

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