Serum Prohepcidin and Hepcidin Levels in Patients with Ankylosing Spondylitis: A Prospective Study

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dc.contributor.authorDagli, Mehmet
dc.contributor.authorYilmaz, Sema
dc.contributor.authorSivrikaya, Abdullah
dc.contributor.authorOzturk, Bahadir
dc.date.accessioned2020-03-26T19:26:18Z
dc.date.available2020-03-26T19:26:18Z
dc.date.issued2016
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractAim: Anemia is a common complication in patients with inflammatory diseases such as ankylosing spondylitis. Recent data suggest that hepcidin is a major mediator of anemia with a central role in iron homeostasis and metabolism. The aim of this study was to evaluate the serum levels of hepcidin and its prohormone, prohepcidin, in patients with ankylosing spondylitis in comparison with healthy controls. Material and Method: Forty patients with ankylosing spondylitis (13 with anemia and 27 without anemia). 20 healthy adults were prospectively enrolled. Complete blood count, erythrocyte sedimentation rate, serum levels of hepcidin, prohepcidin, iron, total iron binding capacity, ferritin, transferrin, and C-reactive protein were measured. Results: Serum levels of prohepcidin and hepcidin were significantly higher in patients with ankylosing spondylitis compared to healthy controls (p<0.005). Positive correlation was determined between the serum hepcidin and prohepcidin levels in patients with ankylosing spondylitis (r=0.725, p <0.001). Discussion: To the best of our knowledge, this is the first report of serum levels of prohepcidin and hepcidin in the patients with ankylosing spondylitis. Serum levels of prohepcidin and hepcidin are closely associated with disease activity in patients with ankylosing spondylitis and might play a role in the pathogenesis of anemia of chronic disease associated with ankylosing spondylitis.en_US
dc.identifier.doi10.4328/JCAM.2451en_US
dc.identifier.endpage41en_US
dc.identifier.issn1309-0720en_US
dc.identifier.issn1309-2014en_US
dc.identifier.issue1en_US
dc.identifier.pmid#YOKen_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage38en_US
dc.identifier.urihttps://dx.doi.org/10.4328/JCAM.2451
dc.identifier.urihttps://hdl.handle.net/20.500.12395/33985
dc.identifier.volume7en_US
dc.identifier.wosWOS:000376566300010en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherDERMAN MEDICAL PUBLen_US
dc.relation.ispartofJOURNAL OF CLINICAL AND ANALYTICAL MEDICINEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAnkylosing Spondylitisen_US
dc.subjectProhepcidinen_US
dc.subjectHepcidinen_US
dc.subjectAnemiaen_US
dc.titleSerum Prohepcidin and Hepcidin Levels in Patients with Ankylosing Spondylitis: A Prospective Studyen_US
dc.typeArticleen_US

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