Effects of beta-endorphin on plasma insulin, glucagon and glucose levels in streptozotocin-induced diabetic rats
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Date
2006
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Publisher
BLACKWELL PUBLISHING
Access Rights
info:eu-repo/semantics/closedAccess
Abstract
Healthy, and insulin-deficient (streptozotocin-induced diabetic, STZ) Sprague-Dawley rats were used to investigate the effects of different doses of ?-endorphin (25 and 50 µg/kg) on plasma ?-endorphin, insulin, glucagon, and glucose levels at 15- and 30-min time points. In experimental groups, plasma ?-endorphin levels were higher at the 15-min than at the 30-min time point in healthy rats; however, in STZ-diabetic rats, ?-endorphin levels were lower at 15 min than at 30 min, indicating that intraperitoneal absorption of ?-endorphin differed between healthy and insulin-deficient rats. ?-endorphin did not affect plasma glucose, insulin, or glucagon at either dose in the healthy group. In the insulin-deficient rats, ?-endorphin at 50 µg/kg reduced plasma glucose levels at the 30-min time point compared to the 25 µg/kg dose, without affecting plasma insulin. Moreover, ?-endorphin at 50 ?g/kg decreased plasma glucagon levels at the 15-min time point in comparison to the 25 ?g/kg dose in insulin-deficient rats. Plasma glucose levels may be reduced in insulin-deficient rats at high ?-endorphin levels regardless of insulin status.
Description
31st Congress of the Federation-of-European-Biochemical-Societies (FEBS) -- JUN 24-29, 2006 -- Istanbul, TURKEY
Keywords
Journal or Series
FEBS JOURNAL
WoS Q Value
Q2
Scopus Q Value
Volume
273
