Effects of beta-endorphin on plasma insulin, glucagon and glucose levels in streptozotocin-induced diabetic rats

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dc.contributor.authorAkalın, Pınar Peker
dc.contributor.authorBaşpınar, Nuri
dc.date.accessioned2020-03-26T17:03:26Z
dc.date.available2020-03-26T17:03:26Z
dc.date.issued2006
dc.departmentSelçuk Üniversitesien_US
dc.description31st Congress of the Federation-of-European-Biochemical-Societies (FEBS) -- JUN 24-29, 2006 -- Istanbul, TURKEYen_US
dc.description.abstractHealthy, and insulin-deficient (streptozotocin-induced diabetic, STZ) Sprague-Dawley rats were used to investigate the effects of different doses of ?-endorphin (25 and 50 µg/kg) on plasma ?-endorphin, insulin, glucagon, and glucose levels at 15- and 30-min time points. In experimental groups, plasma ?-endorphin levels were higher at the 15-min than at the 30-min time point in healthy rats; however, in STZ-diabetic rats, ?-endorphin levels were lower at 15 min than at 30 min, indicating that intraperitoneal absorption of ?-endorphin differed between healthy and insulin-deficient rats. ?-endorphin did not affect plasma glucose, insulin, or glucagon at either dose in the healthy group. In the insulin-deficient rats, ?-endorphin at 50 µg/kg reduced plasma glucose levels at the 30-min time point compared to the 25 µg/kg dose, without affecting plasma insulin. Moreover, ?-endorphin at 50 ?g/kg decreased plasma glucagon levels at the 15-min time point in comparison to the 25 ?g/kg dose in insulin-deficient rats. Plasma glucose levels may be reduced in insulin-deficient rats at high ?-endorphin levels regardless of insulin status.en_US
dc.description.sponsorshipFederat European Biochem Socen_US
dc.identifier.endpage208en_US
dc.identifier.issn1742-464Xen_US
dc.identifier.startpage208en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/20458
dc.identifier.volume273en_US
dc.identifier.wosWOS:000238914001305en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.institutionauthorAkalın, Pınar Peker
dc.institutionauthorBaşpınar, Nuri
dc.language.isoenen_US
dc.publisherBLACKWELL PUBLISHINGen_US
dc.relation.ispartofFEBS JOURNALen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleEffects of beta-endorphin on plasma insulin, glucagon and glucose levels in streptozotocin-induced diabetic ratsen_US
dc.typeConference Objecten_US

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