Chemical composition and biological activities of extracts from three Salvia species: S. blepharochlaena, S. euphratica var. leiocalycina, and S. verticillata subsp amasiaca

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dc.contributor.authorZengin, Gökhan
dc.contributor.authorLlorent-Martinez, Eulogio J.
dc.contributor.authorLuisa Fernandez-de Cordova, Maria
dc.contributor.authorBahadori, Mir Babak
dc.contributor.authorMocan, Andrei
dc.contributor.authorLocatelli, Marcello
dc.contributor.authorAktümsek, Abdurrahman
dc.date.accessioned2020-03-26T19:53:04Z
dc.date.available2020-03-26T19:53:04Z
dc.date.issued2018
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe genus Salvia has recently attracted great attention due to its notable biological activities. Within this context, in this study, the chemical characterization and biological effects of three extracts (dichloromethane (DCM), methanol (MeOH), and water) from three Salvia species (S. blepharochlaena (SB), S. euphratica var. leiocalycina (SE), and S. verticillata subsp. atnasica (SV)) were assessed. For the chemical characterization, the qualitative and quantitative analysis of phenolic components in the methanol extracts was carried out by high-performance liquid chromatography with electrospray ionization mass spectrometry detection (HPLC-UV-ESI-MS). Total phenolic, flavonoid and phenolic acid contents were also studied. Concerning the biological effects, antioxidant (DPPH and ABTS free radical scavenging; ferric (FRAP) and cupric (CUPRAC) reducing power; phosphomo-lybdenum, and metal chelating assays), enzyme inhibitory (cholinesterase, tyrosinase, amylase, glucosidase, lipase, and elastase) and cytotoxic effects (A-549 and MCF-7 cell lines) were evaluated. After the evaluation of the phytochemical profile by HPLC-UV-ESI-MSn, it was observed that the main compound in the analyzed extracts was rosmarinic acid, which was present at high concentrations, particularly in SV, which presented rosmarinic acid levels higher than the usual levels found in other Salvia species or related plants. Generally, the SV-water extract presented the strongest antioxidant abilities with higher levels of total bioactive compounds. However, the studied DCM extracts had higher enzyme inhibitory potentials compared with MeOH and water extracts. SE-DCM exerted the most potent cytotoxic effects, followed by SB-water and SB-MeOH extracts.en_US
dc.identifier.doi10.1016/j.indcrop.2017.09.065en_US
dc.identifier.endpage21en_US
dc.identifier.issn0926-6690en_US
dc.identifier.issn1872-633Xen_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage11en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.indcrop.2017.09.065
dc.identifier.urihttps://hdl.handle.net/20.500.12395/36393
dc.identifier.volume111en_US
dc.identifier.wosWOS:000419407600003en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.relation.ispartofINDUSTRIAL CROPS AND PRODUCTSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectSalviaen_US
dc.subjectAntioxidant activityen_US
dc.subjectFlavonoiden_US
dc.subjectRosmarinic aciden_US
dc.subjectCytotoxic effectsen_US
dc.titleChemical composition and biological activities of extracts from three Salvia species: S. blepharochlaena, S. euphratica var. leiocalycina, and S. verticillata subsp amasiacaen_US
dc.typeArticleen_US

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