Effect of oral immunoglobulin G in experimental necrotizing enterocolitis model [Deneysel nekrotizan enterokolit modelinde agizdan verilen immünglobülin G'nin etkisi]

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dc.contributor.authorYurtçu M.
dc.contributor.authorAydogdu B.
dc.contributor.authorToy H.
dc.contributor.authorGürbílek M.
dc.contributor.authorGünel E.
dc.date.accessioned2020-03-26T17:28:34Z
dc.date.available2020-03-26T17:28:34Z
dc.date.issued2008
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractAim: Investigation of the protective effect of oral immunglobulin(Ig) G on rat intestinum in experimental necrotizing enterocolitis model. Materials and Methods: 40 newborn rats were devided into 4 groups each containing 10 rats. While control (C) group was fed by breast, the rats in necrotizing enterocolitis (N), sham (S), and treatment (T) groups were settled into incubators at 36°C and 60 % humidity and fed, but not by breast. The rats in group C were breast fed. The rats in N group were fed with Formula as soon as they were born. The rats in T group were fed with Formula and 1200 mg/kg/day oral Ig A with 4-hour intervals. The rats in S group were fed with Formula and 0.1 ml/kg/day distilled water which is solvent of Ig. The rats in all groups were weighed and sacrified on fourth day. 2 cm intestinal segment from proximal of ileocaecal valve was used for histopathologic examination, another 10 cm intestinal segment for biochemical examination. After laparotomy, H&E was used for histopathological examination and apoptosis repressor with card Ab-1 citt for immunohistochemical examination. Biochemical parameters such as TNF-?, and IL-6 were evaluated. Results: The rate of mortality in N, S, and T groups was significantly higher than groups C (P=0.038). Significant weight increase in group C was significantly higher than N, S, and T groups (P=0.000). Histopathologic parameters such as villus injury, transmural necrosis in group C were found to be significantly decreased compared with N, S, and T groups according to scoring system (P=0.000). Apoptosis in group C was found to be significantly decreased compared with N, S, and T groups according to scoring system (P=0.001). IL-6 and TNF-? levels were identified to be significantly decreased in group C compared with N, S, and T groups (P<0.05). There was no significant difference among N, S, and T groups (P>0.05). Conclusion: Pure IgG given orally was not identified to decrease intestinal damage and to prevent NEC in experimental NEC model both biochemically and histopathologically.en_US
dc.identifier.endpage57en_US
dc.identifier.issn1305-5194en_US
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage52en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/22804
dc.identifier.volume22en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.relation.ispartofCocuk Cerrahisi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectImmunoglobulin Gen_US
dc.subjectNecrotizing enterocolitisen_US
dc.subjectNewbornen_US
dc.subjectTreatmenten_US
dc.titleEffect of oral immunoglobulin G in experimental necrotizing enterocolitis model [Deneysel nekrotizan enterokolit modelinde agizdan verilen immünglobülin G'nin etkisi]en_US
dc.typeArticleen_US

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