Pharmacokinetics of ceftriaxone following single ascending intravenous doses in sheep

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dc.contributor.authorCorum, Duygu Durna
dc.contributor.authorCorum, Orhan
dc.contributor.authorAltan, Feray
dc.contributor.authorFaki, Hatice Eser
dc.contributor.authorBahcivan, Emre
dc.contributor.authorEr, Ayse
dc.contributor.authorUney, Kamil
dc.date.accessioned2020-03-26T19:55:02Z
dc.date.available2020-03-26T19:55:02Z
dc.date.issued2018
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe objective of this study was to evaluate the pharmacokinetics of CTX following intravenous administration of ascending doses in sheep. In this study, six clinically healthy Akkaraman sheep (2.4 +/- 0.4 years and 50 +/- 3 kg of body weight) were used. CTX was administered intravenously to each sheep at 20, 40, and 80 mg/kg doses in a crossover design with a 15-day washout period. Plasma concentrations of CTX were measured using the high-performance liquid chromatography-UV method. Pharmacokinetic parameters were calculated by non-compartmental analysis. CTX was well tolerated following administration at 20, 40, and 80 mg/kg doses. The elimination half-life following administration of 40 and 80 mg/kg doses were significantly longer than that of 20 mg/kg dose (P < 0.05). The volume of distribution at steady state was similar among the groups (P > 0.05). When compared to 20 mg/kg, dose-normalized AUC(0-infinity) at the 80 mg/kg dose significantly increased (P < 0.05). The relation between dose and AUC(0-infinity) was linear. Our study showed that CTX can be used at 12-h intervals for 20, 40, and 80 mg/kg doses to maintain T > minimum inhibitory concentration (MIC) of > 40% for the treatment of infections caused by bacteria with MIC values <= 2, <= 4, and <= 16 mu g/mL, respectively. This information may be helpful in adjusting the dosage regimen, but there is a need for future work.en_US
dc.identifier.doi10.1016/j.smallrumres.2018.07.019en_US
dc.identifier.endpage112en_US
dc.identifier.issn0921-4488en_US
dc.identifier.issn1879-0941en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage108en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.smallrumres.2018.07.019
dc.identifier.urihttps://hdl.handle.net/20.500.12395/36840
dc.identifier.volume169en_US
dc.identifier.wosWOS:000454968700018en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.relation.ispartofSMALL RUMINANT RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCeftriaxoneen_US
dc.subjectPharmacokineticsen_US
dc.subjectAscending doseen_US
dc.subjectSheepen_US
dc.titlePharmacokinetics of ceftriaxone following single ascending intravenous doses in sheepen_US
dc.typeArticleen_US

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