HPLC-MS/MS-based metabolic profiling and pharmacological properties of extracts and infusion obtained from Amelanchier parviflora var. dentata

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dc.contributor.authorZengin, Gökhan
dc.contributor.authorDiuzheva, Alina
dc.contributor.authorJeko, Jozsef
dc.contributor.authorCziaky, Zoltan
dc.contributor.authorBulut, Gizem
dc.contributor.authorDoğan, Ahmet
dc.contributor.authorHaznedaroğlu, Mehmet Zeki
dc.date.accessioned2020-03-26T19:54:11Z
dc.date.available2020-03-26T19:54:11Z
dc.date.issued2018
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractArnelanchierparviflora var. dentata is an endemic medicinal plant traditionally consumed to treat stomach pain, cardiovascular diseases, and urinary tract infections in Turkey's folk medicine. Although Amelanchier genus is an excellent source of phytochemicals with a panoply of biological activities, no report has been made available on Amelanchier parviflora var. dentata. Thus, the metabolic profiles of methanol, ethyl acetate, and water extracts were obtained using HPLC-MS/MS. Besides, the pharmacological properties such as antioxidant activity and enzyme inhibition effects against acetyl/butyrylcholinesterase, tyrosinase, alpha-amylase, and alpha-glucosidase were evaluated. In total, 62, 38, and 16 metabolites were Identified from the methanolic, water, and ethyl acetate extracts, respectively. The identified metabolites belong to anthocyanins, phenolic acids, and flavonoids. The tested extracts exhibited different enzyme inhibitory activity against cholinesterases (acetylcholinesterase: 0.52-2.47 mg GEs/g extract and butyrylcholinesterase: 0.47-3.59 mg GEs/g extract), tyrosinase (19,0-145.54 mg KAEs/g extract), alpha-amylase (0.23-1.10 mmol ACEs/g extract), and alpha-glucosidase (8.89-9.92 mmol ACEs/ g extract). Evidence from the present study supports the necessity for more research in an endeavor to discover biologically active secondary metabolites from A. parviflora to manage specific ailments.en_US
dc.identifier.doi10.1016/j.indcrop.2018.08.042en_US
dc.identifier.endpage706en_US
dc.identifier.issn0926-6690en_US
dc.identifier.issn1872-633Xen_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage699en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.indcrop.2018.08.042
dc.identifier.urihttps://hdl.handle.net/20.500.12395/36680
dc.identifier.volume124en_US
dc.identifier.wosWOS:000447569100081en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.relation.ispartofINDUSTRIAL CROPS AND PRODUCTSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAmelanchier parvifloraen_US
dc.subjectAntioxidantsen_US
dc.subjectChemical fingerprintsen_US
dc.subjectEnzyme inhibitorsen_US
dc.subjectPhenolicsen_US
dc.subjectAnthocyaninsen_US
dc.titleHPLC-MS/MS-based metabolic profiling and pharmacological properties of extracts and infusion obtained from Amelanchier parviflora var. dentataen_US
dc.typeArticleen_US

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