One-pot synthesis of biocompatible boronic acid-functionalized poly(methyl methacrylate) nanoparticles at sub-100 nm scale for glucose sensing

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dc.contributor.authorSakalak, Huseyin
dc.contributor.authorUlasan, Mehmet
dc.contributor.authorYavuz, Emine
dc.contributor.authorCamli, Sevket Tolga
dc.contributor.authorYavuz, Mustafa Selman
dc.date.accessioned2020-03-26T18:51:53Z
dc.date.available2020-03-26T18:51:53Z
dc.date.issued2014
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractPoly(methyl methacrylate) nanoparticles containing 4-vinylphenyl boronic acid were synthesized in one pot by surfactant-free emulsion polymerization. The nanoparticles were characterized by scanning electron microscopy and dynamic light scattering. Boron content in the nanoparticles was confirmed by electron-dispersive X-ray spectroscopy. In polymerization process, several co-monomer ratios were studied in order to obtain optimum nanoparticle size. Average hydrodynamic diameter and polydispersity index of nanoparticles versus variation of acetone percentage in the solvent mixture and total monomer concentration were investigated. The effect of boronic acid concentration in the monomer mixture on nanoparticle size and size distribution was also reported. Without further functionalization to the nanoparticles, the catechol dye, alizarin red S, was bound to boronic acid-containing nanoparticles. These nanoparticles behave as a nanosensor by which glucose or fructose can be easily detected. Dye-containing nanoparticles were undertaken displacement reaction by glucose or fructose. The glucose or fructose content was also monitored by UV-Visible spectrophotometer. Furthermore, cytotoxicity studies of boronic acid-carrying poly(methyl methacrylate) nanoparticles were carried out in 3T3 cells, which showed no toxicity effect on the cells.en_US
dc.description.sponsorshipSelcuk University Scientific Research FundSelcuk University [12201077]; TUBITAKTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [112M096, COST TD1004]en_US
dc.description.sponsorshipThis work was supported by Selcuk University Scientific Research Fund (S.U. BAP no. 12201077) and TUBITAK (Project No. 112M096, COST TD1004). The authors are grateful to Advanced Technology Research and Application Center of Selcuk University for their kind help regarding the analysis (SEM, EDX, DLS, UV-Vis). The authors thank to Dr. Pembegul UYAR for providing 3T3 cells as a kind gift and her valuable guidance.en_US
dc.identifier.doi10.1007/s11051-014-2767-6en_US
dc.identifier.issn1388-0764en_US
dc.identifier.issn1572-896Xen_US
dc.identifier.issue12en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s11051-014-2767-6
dc.identifier.urihttps://hdl.handle.net/20.500.12395/31042
dc.identifier.volume16en_US
dc.identifier.wosWOS:000346697000032en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSPRINGERen_US
dc.relation.ispartofJOURNAL OF NANOPARTICLE RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectDiol sensingen_US
dc.subjectNanosensorsen_US
dc.subjectPoly(methyl methacrylate) nanoparticlesen_US
dc.subjectSurfactant-free emulsion polymerizationen_US
dc.subjectGlucoseen_US
dc.subjectFructoseen_US
dc.titleOne-pot synthesis of biocompatible boronic acid-functionalized poly(methyl methacrylate) nanoparticles at sub-100 nm scale for glucose sensingen_US
dc.typeArticleen_US

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