A Comparative Study of Different Solvents and Extraction Techniques on the Anti-oxidant and Enzyme Inhibitory Activities of Adansonia digitata L. (Baobab) Fruit Pulp

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dc.authorid0000-0002-8901-6484
dc.contributor.authorHussain, Zainab T. E.
dc.contributor.authorYagi, Sakina
dc.contributor.authorMahomoodally, Mohamad Fawzi
dc.contributor.authorMohammed, Ibrahim
dc.contributor.authorZengin, Gökhan
dc.date.accessioned2020-03-26T20:12:15Z
dc.date.available2020-03-26T20:12:15Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Fen Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractAdansonia digitata L. (Malvaceae), also known as Baobab, is well known in Africa for its significant role in international trade and as important source of food, folk medicine and income to rural communities in Africa. The fruit pulp have been used in Sudan and many other countries as beverages and in traditional medicine for the treatment of malaria, fever and many gastrointestinal diseases. The objective of the study was to determine the best method for extraction of phenolic rich crude extracts from A. digitata fruit pulp with high anti-oxidant (phosphomolybdenum, antiradical, reducing power and ferrous chelating) activity and enzyme inhibition activity against acetylcholinesterase (AChE), butyrylcholinesterase (BChE), tyrosinase, a-glucosidase, and a-amylase. Water, ethanol and 50% ethanol extracts were prepared using maceration, decoction and microwave techniques. Fruit pulp of A. digitata showed significant (p < .05) variable phenolic contents, anti-oxidant and enzyme inhibition capacity among solvent type and method of extraction. Microwave technique showed the highest polyphenolic content (66.40 +/- 0.32 mg GAE/g) extracted by 50% EtOH, flavonoids (42.15 +/- 0.12 mg QE/g) and anthocyanidin contents (2.37 +/- 0.06 mg GAE/g) obtained by water. The highest anti-oxidant activity in all the five assays used, was obtained from EtOH extract subjected to maceration. Moreover, microwave technique improved significantly the anti-oxidant activity of 50% EtOH extract. The highest AChE inhibition activity was observed in the three techniques used when using 50% EtOH as solvent while maceration and decoction were effective for EtOH solvent. The highest activity against BChE was performed by EtOH extract subjected to microwave extraction. Epicatechin or (+)-Catechin were the major compounds obtained in all extracts except for 50% EtOH extracts obtained by maceration and decoction which were dominated by the presence of prorocatechuic acid. It is argued that the solvent used and extraction method had an influence on anti-oxidant and enzyme inhibition activities of extracts. In conclusion, maceration and ethanol are recommended as the appropriate extraction method and solvent to obtain phytoconstituents with highest anti-oxidant activities from fruit pulp of Baobab for pharmaceutical and nutraceutical development. (C) 2019 SAAB. Published by Elsevier B.V. All rights reserved.en_US
dc.identifier.citationHussain, Z. T. E., Yagi, S., Mahomoodally, M. F., Mohammed, I., Zengin, G. (2019). A comparative study of different solvents and extraction techniques on the anti-oxidant and enzyme inhibitory activities of Adansonia digitata L. (Baobab) fruit pulp. South African Journal of Botany, 126, 207-213. doi: https://dx.doi.org/10.1016/j.sajb.2019.01.034
dc.identifier.doi10.1016/j.sajb.2019.01.034en_US
dc.identifier.endpage213en_US
dc.identifier.issn0254-6299en_US
dc.identifier.issn1727-9321en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage207en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.sajb.2019.01.034
dc.identifier.urihttps://hdl.handle.net/20.500.12395/37395
dc.identifier.volume126en_US
dc.identifier.wosWOS:000489157200024en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorZengin, Gökhan
dc.language.isoenen_US
dc.publisherELSEVIERen_US
dc.relation.ispartofSouth African Journal of Botanyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAdansonia digitataen_US
dc.subjectPhenolicsen_US
dc.subjectAnti-oxidanten_US
dc.subjectBioactivityen_US
dc.subjectExtractionen_US
dc.subjectNeuroprotectionen_US
dc.subjectDiabetesen_US
dc.subjectFenolikler
dc.subjectAntioksidan
dc.subjectBiyoaktivite
dc.subjectEkstraksiyon
dc.subjectNöroproteksiyon
dc.subjectDiyabet
dc.titleA Comparative Study of Different Solvents and Extraction Techniques on the Anti-oxidant and Enzyme Inhibitory Activities of Adansonia digitata L. (Baobab) Fruit Pulpen_US
dc.typeArticleen_US

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