Chemical characterization, antioxidant, enzyme inhibitory and cytotoxic properties of two geophytes: Crocus pallasii and Cyclamen cilicium

Basit Öğe Kaydı
dc.contributor.authorZengin, Gökhan
dc.contributor.authorMahomoodally, Mohamad Fawzi
dc.contributor.authorSinan, K. I.
dc.contributor.authorPicot-Allain, M. C. N.
dc.contributor.authorYıldıztugay, Evren
dc.contributor.authorCziáky, Z.
dc.contributor.authorJek?, J.
dc.date.accessioned2020-03-26T20:20:44Z
dc.date.available2020-03-26T20:20:44Z
dc.date.issued2020
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe Crocus and Cyclamen genus have been reported to possess diverse biological properties. In the present investigation, two geophytes from these genus, namely Crocus pallasi and Cyclamen cilicium have been studied. The in vitro antioxidant, enzyme inhibitory, and cytotoxic effects of the methanol extracts of Crocus pallasii and Cyclamen cilicium aerial and underground parts were investigated. Antioxidant abilities of the extracts were investigated via different antioxidant assays (metal chelating, radical quenching (ABTS and DPPH), reducing power (CUPRAC and FRAP) and phosphomolybdenum). Cholinesterases, amylase, tyrosinase, and glucosidase were used as target enzymes for detecting enzyme inhibitory abilities of the samples. Regarding the cytotoxic abilities, breast cancer cell lines (MDA-MB 231 and MCF-7) and prostate cancer cell lines (DU-145) were used. The flowers extracts of Crocus pallasii and C. cilicium possessed the highest flavonoid content. The highest phenolic content was recorded from C. cilicium root extract (47.62 mg gallic acid equivalent/g extract). Cyclamen cilicium root extract showed significantly (p < 0.05) high radical scavenging (94.28 and 139.60 mg trolox equivalent [TE]/g extract, against DPPH and ABTS radicals, respectively) and reducing potential (173.30 and 109.53 mg TE/g extract, against CUPRAC and FRAP, respectively). The best acetylcholinesterase, glucosidase and tyrosinase inhibition was observed in C. cilicium root (4.46 mg GALAE/g; 15.75 mmol ACAE/g; 136.99 mg KAE/g, respectively). Methanolic extracts of C. pallasii and C. cilicium showed toxicity against breast cancer cell lines. In light of the above findings, C. cilicium might be considered as an interesting candidate in the development of anti-cancer agent coupled with antioxidant properties. © 2020 Elsevier Ltden_US
dc.identifier.doi10.1016/j.foodres.2020.109129en_US
dc.identifier.issn0963-9969en_US
dc.identifier.pmid32466933en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.foodres.2020.109129
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38656
dc.identifier.volume133en_US
dc.identifier.wosWOS:000536130000012en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Ltden_US
dc.relation.ispartofFood Research Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAntioxidanten_US
dc.subjectBioactive agentsen_US
dc.subjectBreast canceren_US
dc.subjectCrocusen_US
dc.subjectCyclamenen_US
dc.subjectProstate canceren_US
dc.titleChemical characterization, antioxidant, enzyme inhibitory and cytotoxic properties of two geophytes: Crocus pallasii and Cyclamen ciliciumen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
Biyoteknoloji/Makale Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu