Diabetes mellitus-and cooling-induced bladder contraction: An in vitro study

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dc.contributor.authorAtalik K.E.
dc.contributor.authorOkudan N.
dc.contributor.authorGokbel H.
dc.contributor.authorKalkan S.
dc.contributor.authorCuce G.
dc.date.accessioned2020-03-26T18:06:02Z
dc.date.available2020-03-26T18:06:02Z
dc.date.issued2010
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe effects of diabetes mellitus during cooling on ACh-and KCl-induced responses were investigated in rat urinary bladder. Diabetes was induced in the rats by 50 mg/kg streptozotocin via an intraperitoneal injection. Rats' body and bladder weights were measured. The isometric tension to ACh (10-9 -3 × 10-4 M) and KCl (5-100 mM) in strips of urinary detrusor muscle of diabetic and non-diabetic rats, in organ baths at 37 and 28°C were recorded. The body weights were significantly decreased and the bladder weights increased in STZ-induced diabetic group compared to the non-diabetic group. ACh and KCl caused concentration-dependent contractions of urinary bladders from non-diabetic and STZ-induced diabetic rats. During cooling, the sensitivity and the maximal response were significantly higher than those during 37°C, both in non-diabetic and diabetic preparations. Cooling of detrusor muscle preparations induces a graded contraction inversely proportional to the temperature in diabetic rats. It may be assumed that the cooling response involves the same mechanisms in the diabetic and non-diabetic animals.en_US
dc.identifier.doi10.1540/jsmr.46.175en_US
dc.identifier.endpage183en_US
dc.identifier.issn0916-8737en_US
dc.identifier.issue4en_US
dc.identifier.pmid20859065en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage175en_US
dc.identifier.urihttps://dx.doi.org/10.1540/jsmr.46.175
dc.identifier.urihttps://hdl.handle.net/20.500.12395/25604
dc.identifier.volume46en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofJournal of Smooth Muscle Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCarbacholen_US
dc.subjectCoolingen_US
dc.subjectDiabetes mellitusen_US
dc.subjectPotassium chlorideen_US
dc.subjectRat urinary bladderen_US
dc.titleDiabetes mellitus-and cooling-induced bladder contraction: An in vitro studyen_US
dc.typeArticleen_US

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