The Risk of Severe Hypoglycemia in Patients with type 2 Diabetes Mellitus Starting Insulin Therapy with Premixed Insulin Analogues Taken Twice Daily: An Observational Study in Turkish Patients

Küçük Resim



Dergi Başlığı

Dergi ISSN

Cilt Başlığı


Turkiye Klinikleri

Erişim Hakkı



Purpose: To assess the risk of severe hypoglycemia in Turkish patients with type 2 diabetes mellitus (T2DM) starting insulin therapy with premixed insulin analogues alone or in combination with oral antihyperglycemic medications. Material and Method: Data from a subset of Turkish patients who participated in a 1-year, multinational, multicenter, prospective observational study were evaluated. Insulin treatment was initiated using commonly prescribed premixed regimens: insulin lispro mixture 25/75 (25% insulin lispro, 75% insulin lispro protamine suspension) or biphasic insulin aspart 30/70 (30% insulin aspart, 70% insulin aspart protamine suspension) twice daily. Results: Of the 154 patients treated, 61 (39.6%) were male with a mean age of 56 years and a T2DM duration of 8.9 years. Twelve patients (7.8%) experienced ?1 episode of severe hypoglycemia, but all recovered. The severe hypoglycemic rate was 0.14 episodes/patient-year. The mean glycated hemoglobin decreased by 2.7% (10.4% to 7.8%) and fasting plasma glucose by 115.9 mg/dL (265.3 mg/dL to 157.6 mg/dL) (p<0.0001). Self-monitored blood glucose (2-hour post morning meal) decreased by 163.3 mg/dL (327.0 mg/dL to 216.2 mg/dL; p<0.0001). Self-monitored blood glucose level was low, particularly at the 2-hour post evening meal. Body mass index increased by 1.4 kg/m2, and total daily insulin dose by 4.2 IU. Discussion: In Turkish patients with T2DM, initiation of premixed insulin analogues during routine clinical care significantly improves glycemic control during the first year of treatment, but comes with a risk for severe hypoglycemia. Improvements in physician and patient education within the Turkish population regarding hypoglycemia management may be of benefit.


Anahtar Kelimeler

Observational study, Premixed insulin analogues, Severe hypoglycemic episode, Type 2 diabetes mellitus


Turkish Journal of Endocrinology and Metabolism

WoS Q Değeri

Scopus Q Değeri







Gönen, M. S., Yürümez, A., Hersek, Ö., Altunoğlu, E., Rakıcı, H., Scism-Bacon, J., Abdulnabi, R. (2013). The risk of severe hypoglycemia in patients with type 2 diabetes mellitus starting insulin therapy with premixed insulin analogues taken twice daily: An observational study in Turkish patients. Turkish Journal of Endocrinology and Metabolism, 17, (4), 83-88.