The Risk of Severe Hypoglycemia in Patients with type 2 Diabetes Mellitus Starting Insulin Therapy with Premixed Insulin Analogues Taken Twice Daily: An Observational Study in Turkish Patients

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dc.contributor.authorGönen, Mustafa Sait
dc.contributor.authorYürümez, Adem
dc.contributor.authorHersek, Ömer
dc.contributor.authorAltunoğlu, Esma
dc.contributor.authorRakıcı, Halil
dc.contributor.authorScism-Bacon, Jamie
dc.contributor.authorAbdulnabi, Radhi
dc.date.accessioned2020-03-26T18:48:08Z
dc.date.available2020-03-26T18:48:08Z
dc.date.issued2013
dc.departmentSelçuk Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimlerien_US
dc.description.abstractPurpose: To assess the risk of severe hypoglycemia in Turkish patients with type 2 diabetes mellitus (T2DM) starting insulin therapy with premixed insulin analogues alone or in combination with oral antihyperglycemic medications. Material and Method: Data from a subset of Turkish patients who participated in a 1-year, multinational, multicenter, prospective observational study were evaluated. Insulin treatment was initiated using commonly prescribed premixed regimens: insulin lispro mixture 25/75 (25% insulin lispro, 75% insulin lispro protamine suspension) or biphasic insulin aspart 30/70 (30% insulin aspart, 70% insulin aspart protamine suspension) twice daily. Results: Of the 154 patients treated, 61 (39.6%) were male with a mean age of 56 years and a T2DM duration of 8.9 years. Twelve patients (7.8%) experienced ?1 episode of severe hypoglycemia, but all recovered. The severe hypoglycemic rate was 0.14 episodes/patient-year. The mean glycated hemoglobin decreased by 2.7% (10.4% to 7.8%) and fasting plasma glucose by 115.9 mg/dL (265.3 mg/dL to 157.6 mg/dL) (p<0.0001). Self-monitored blood glucose (2-hour post morning meal) decreased by 163.3 mg/dL (327.0 mg/dL to 216.2 mg/dL; p<0.0001). Self-monitored blood glucose level was low, particularly at the 2-hour post evening meal. Body mass index increased by 1.4 kg/m2, and total daily insulin dose by 4.2 IU. Discussion: In Turkish patients with T2DM, initiation of premixed insulin analogues during routine clinical care significantly improves glycemic control during the first year of treatment, but comes with a risk for severe hypoglycemia. Improvements in physician and patient education within the Turkish population regarding hypoglycemia management may be of benefit.en_US
dc.identifier.citationGönen, M. S., Yürümez, A., Hersek, Ö., Altunoğlu, E., Rakıcı, H., Scism-Bacon, J., Abdulnabi, R. (2013). The risk of severe hypoglycemia in patients with type 2 diabetes mellitus starting insulin therapy with premixed insulin analogues taken twice daily: An observational study in Turkish patients. Turkish Journal of Endocrinology and Metabolism, 17, (4), 83-88.
dc.identifier.doi10.4274/Tjem.2134en_US
dc.identifier.endpage88en_US
dc.identifier.issn1301-2193en_US
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage83en_US
dc.identifier.urihttps://dx.doi.org/10.4274/Tjem.2134
dc.identifier.urihttps://hdl.handle.net/20.500.12395/30072
dc.identifier.volume17en_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorGönen, Mustafa Sait
dc.language.isoenen_US
dc.publisherTurkiye Kliniklerien_US
dc.relation.ispartofTurkish Journal of Endocrinology and Metabolismen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectObservational studyen_US
dc.subjectPremixed insulin analoguesen_US
dc.subjectSevere hypoglycemic episodeen_US
dc.subjectType 2 diabetes mellitusen_US
dc.titleThe Risk of Severe Hypoglycemia in Patients with type 2 Diabetes Mellitus Starting Insulin Therapy with Premixed Insulin Analogues Taken Twice Daily: An Observational Study in Turkish Patientsen_US
dc.title.alternativeİnsulin Tedavisine Günde İki Kez (BID) Hazırkarışım İnsulin Analogu ile Başlayan Tip 2 Diabetik Hastalarda Ciddi Hipoglisemi Riski: Türk Hastalarda Gözlemsel Çalışmaen_US
dc.typeArticleen_US

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