The effect of dexmedetomidine in the prefrontal cortex of rabbits after subarachnoidal hemorrhage

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dc.contributor.authorEser, Olcay
dc.contributor.authorCosar, Murat
dc.contributor.authorFidan, Huseyin
dc.contributor.authorSahin, Onder
dc.contributor.authorBuyukbaS, Sadik
dc.contributor.authorEla, Yuksel
dc.contributor.authorSongur, Ahmet
dc.date.accessioned2020-03-26T17:04:31Z
dc.date.available2020-03-26T17:04:31Z
dc.date.issued2006
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: This study was undertaken to examine the possible neuroprotective effect of dexmedetomidine in the prefrontal cortex of vasospastic subarachnoid hemorrhage (SAH) rabbits. Materials and Methods: Experimental SAH was performed to the 12 of 18 New Zealand rabbits by injecting 0.9 ml of autologous arterial blood/1 kg of body weight to cisterna magna. Craniotomy procedure was performed to the rest 6 rabbits (control group) (Group A) except performing experimental SAH. Forty eight hours after SAH was established, 5 mL/kg/hour 0.9% sodium chloride were infused to the SAH-alone group (n=6) (Group B) and 5 mu g/kg/h dexmedetomidine were infused to the SAH-dexmedetomidine group (n=6) (Group C) for 2 hours. Rabbits of all groups were sacrificed via penthotal after 24 hours following this drug administration processes. Brains were removed from the skull totally, prefrontal cortices were blocked from the right hemisphere for histopathological study, and prefrontal cortex of left hemispheres were dissected for biochemical analyses. So, malondialdehyde levels, activities of xantine oxidase, and superoxide dismutase were studied from the left prefrontal cortex. Results: The histopathological results showed that dexmedetomidine has neuroprotective effect in SAH induced prefrontal cortex injuries. The antioxidant parameters also supported the neuroprotective effect of dexmedetomidine. Conclusion: The present study showed the neuroprotective effect of dexmedetomidine in the prefrontal cortex of rabbits after vasospastic subarachnoid hemorrhage.en_US
dc.identifier.endpage194en_US
dc.identifier.issn0941-9500en_US
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage189en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/20718
dc.identifier.volume13en_US
dc.identifier.wosWOS:000249575500005en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherUNIVERSITATSVERLAG ULM GMBHen_US
dc.relation.ispartofNEUROLOGY PSYCHIATRY AND BRAIN RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectcerebral ischemiaen_US
dc.subjectdexmedetomidineen_US
dc.subjectsubarachnoid hemorrhageen_US
dc.subjectvasospasmen_US
dc.subjectprefrontal cortexen_US
dc.titleThe effect of dexmedetomidine in the prefrontal cortex of rabbits after subarachnoidal hemorrhageen_US
dc.typeArticleen_US

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