Serum fetuin-A, coenzyme Q(10) and plasma fatty acid levels in obese and healthy subjects

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dc.contributor.authorYerlikaya, Humeyra
dc.contributor.authorMehmetoglu, Idris
dc.contributor.authorKurban, Sevil
dc.date.accessioned2020-03-26T18:16:07Z
dc.date.available2020-03-26T18:16:07Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate serum fetuin-A, coenzyme Q(10) and plasma fatty acids profiles in obese and healthy subjects. Subjects & Methods: The study was performed on a total of 105 obese subjects (22 male and 83 female) aged 38.3 +/- 12.9 years and 80 healthy subjects (20 male and 60 female) aged 36.3 +/- 11.3 years. Plasma fatty acid composition was measured by gas chromatography-mass spectrometry, serum coenzyme Q(10) level was measured by high-performance liquid chromatography and serum fetuin-A level was measured by ELISA methods. Results: Plasma myristic acid, palmitic acid, palmitoleic acid, 10c-heptadecanoic acid, linoleic acid, heneikosanoic acid, saturated fatty acids levels and Delta 9-desaturase activity of the obese subjects were significantly higher (p < 0.05), whereas behenic acid levels and elongase activity were significantly lower (p < 0.05) than the same parameters in the controls. There were no significant differences between plasma monounsaturated fatty acids, polyunsaturated fatty acids, serum coenzyme Q(10) and fetuin-A levels in either of the groups. Discussion: Our results demonstrate that plasma saturated fatty acid levels of obese subjects were significantly increased. Also, the plasma levels of some fatty acids and enzyme activities of both groups were significantly different from each other. The role of these findings in the development of obesity needs to be investigated further. In addition, our results, demonstrating that fetuin-A levels were not associated with BMI or waist circumference, suggest that fetuin-A may not play a critical role in the development of obesity.en_US
dc.description.sponsorshipUniversity of Selcuk, Scientific Research Projects Department (BAP), Konya TurkeySelcuk University [09102048]en_US
dc.description.sponsorshipThis research was supported by Grant 09102048 from University of Selcuk, Scientific Research Projects Department (BAP), Konya Turkey. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.en_US
dc.identifier.doi10.2217/CLP.11.48en_US
dc.identifier.endpage624en_US
dc.identifier.issn1758-4299en_US
dc.identifier.issn1758-4302en_US
dc.identifier.issue5en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage615en_US
dc.identifier.urihttps://dx.doi.org/10.2217/CLP.11.48
dc.identifier.urihttps://hdl.handle.net/20.500.12395/26814
dc.identifier.volume6en_US
dc.identifier.wosWOS:000296979100014en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherFUTURE MEDICINE LTDen_US
dc.relation.ispartofCLINICAL LIPIDOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectcoenzyme Q(10)en_US
dc.subjectfetuin-Aen_US
dc.subjectobesityen_US
dc.subjectplasma fatty aciden_US
dc.titleSerum fetuin-A, coenzyme Q(10) and plasma fatty acid levels in obese and healthy subjectsen_US
dc.typeArticleen_US

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