Pulmonary Adenocarcinoma Presented With Lambert Eaton Myasthenic Syndrome

dc.contributor.authorEren, Fettah
dc.contributor.authorAygül, Recep
dc.contributor.authorÖztürk, Şerefnur
dc.date.accessioned2020-03-26T20:12:05Z
dc.date.available2020-03-26T20:12:05Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü en_US
dc.description.abstractParaneoplastic neurological syndrome is an autoimmune disease caused by distant effect of tumor. Lambert - Eatonmyasthenic syndrome (LEMS) is a paraneoplastic disease that is associated with voltage-dependent calcium channelantibodies. These autoantibodies affect especially presynaptic neuromuscular area. A 65 -year-old male patient admitted tohospital with complaint of dizziness, walking difficulty, and difficulty in getting up stairs. Neur ological examinationshowed mild muscle weakness proximal of lower extremities. Deep tendon reflexes were hypoactive. Sensory nerveconduction was normal in the electroneuromyography. All motor nerve compound muscle action potential (CMAP)amplitudes were decreased. After 10 seconds of exercise, amplitude increased more than 100%. More than 10% decrementwas observed at low frequencies in ulnar repetitive nerve stimulation. More than 200% increment was observed with 50 Hztetanic stimulation. Lung adenocarcinoma was diagnosed with thorax computerized tomography and bronchoscopicbiopsy. In the electrophysiological analyses of LEMS, significant amplitude increment is diagnostic with high frequencytetanic stimulation. Increment following short-term exercise is an easier alternative method to tetanic stimulation.en_US
dc.identifier.citationEren, F., Aygül, R., Öztürk, Ş. (2019). Pulmonary Adenocarcinoma Presented With Lambert Eaton Myasthenic Syndrome. Eastern Journal of Medicine, 24(3), 386-389.
dc.identifier.doi10.5505/ejm.2019.58855en_US
dc.identifier.endpage389en_US
dc.identifier.issn1301-0883en_US
dc.identifier.issn1339-3886en_US
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage386en_US
dc.identifier.urihttps://dx.doi.org/10.5505/ejm.2019.58855
dc.identifier.urihttp://www.trdizin.gov.tr/publication/paper/detail/TXpJM01Ea3hNUT09
dc.identifier.urihttps://hdl.handle.net/20.500.12395/37332
dc.identifier.volume24en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorAygül, Recep
dc.institutionauthorÖztürk, Şerefnur
dc.language.isoenen_US
dc.relation.ispartofEastern Journal of Medicineen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectDiş Hekimliğien_US
dc.subjectFarmakoloji ve Eczacılıken_US
dc.subjectToksikolojien_US
dc.titlePulmonary Adenocarcinoma Presented With Lambert Eaton Myasthenic Syndromeen_US
dc.typeArticleen_US

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