Differences in the Somatotropic Axis, in Blood Cortisol, Insulin and Thyroid Hormone Concentrations Between Two Pig Genotypes With Markedly Divergent Growth Rates and the Effects of Growth Hormone Treatment

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dc.contributor.authorElsaesser, F.
dc.contributor.authorPfaffl, M. W.
dc.contributor.authorMeyer, H. H. D.
dc.contributor.authorSerpek, B.
dc.contributor.authorSauerwein, H.
dc.date.accessioned2020-03-26T16:38:52Z
dc.date.available2020-03-26T16:38:52Z
dc.date.issued2002
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe intention of the current study was to gain more insight into the endocrine and molecular control mechanisms of growth in the pig. For this purpose various growth related parameters were determined in 4-month-old barrows of two extreme pig genotyes, the small, obese Gottingen Miniature (GM) and the large and lean German Landrace (DL). Mean growth hormone (GH) concentration, GH pulse frequency and GH pulse amplitude did not differ between breeds. Likewise, plasma IGF-1, thyroxine, tri-iodothyronine (T) concentrations were similar in both breeds. However the plasma GH response (maximum level and area under curve) to a single i.v. injection of GHRH in DL was higher than in GM (P < 0.05). Furthermore, basal plasma insulin and in particular plasma cortisol concentrations were higher in GM compared with DL pigs (P < 0.05 and <0.01 respectively). Analysis of cortisol during 4-h frequent blood sampling indicated higher cortisol amplitudes in GM compared with DL (P &LE; 0.01). Specific bGH-binding to hepatic membrane preparations was not different between breeds and IGF-1 m RNA concentrations determined by reverse transcription-polymerase chain reaction in liver, m. semimenbranosus and m. longissimus dorsi were similar in both breeds. I.m. treatment with recombinant porcine somatotropin (rpST, 70 &mu;g/kg live weight) over an 8-day period in contemporary barrows increased without any breed difference, plasma IGF-1, T-3 and insulin Concentrations and hepatic specific bGH-binding, but did not affect thyroxine or cortisol concentrations in plasma. IGF-1 gene expression was also elevated in liver and muscle tissues in rpST-treated animals without obvious breed effects. The observations underline the complexity of the hormonal and molecular control of growth and support the notion that differences in growth potential are the consequence of differences at various levels of the somatotropic axis and apparently relate to differences in other control systems of energy metabolism such as the pituitary adrenal axis or the endocrine pancreas as well.en_US
dc.identifier.citationElsaesser, F., Pfaffl, M. W., Meyer, H. H. D., Serpek, B., Sauerwein, H., (2002). Differences in the Somatotropic Axis, in Blood Cortisol, Insulin and Thyroid Hormone Concentrations Between Two Pig Genotypes With Markedly Divergent Growth Rates and the Effects of Growth Hormone Treatment. Animal Science, (74), 423-430. Doi: 10.1017/S1357729800052577
dc.identifier.doi10.1017/S1357729800052577en_US
dc.identifier.endpage430en_US
dc.identifier.issn1357-7298en_US
dc.identifier.startpage423en_US
dc.identifier.urihttps://dx.doi.org/10.1017/S1357729800052577
dc.identifier.urihttps://hdl.handle.net/20.500.12395/17922
dc.identifier.volume74en_US
dc.identifier.wosWOS:000176837300004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.institutionauthorElsaesser, F.
dc.institutionauthorSerpek, B.
dc.language.isoenen_US
dc.publisherBritish Soc Animal Scienceen_US
dc.relation.ispartofAnimal Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectgenotypesen_US
dc.subjectgrowthen_US
dc.subjecthydrocortisoneen_US
dc.subjectpigsen_US
dc.subjectsomatotropinen_US
dc.titleDifferences in the Somatotropic Axis, in Blood Cortisol, Insulin and Thyroid Hormone Concentrations Between Two Pig Genotypes With Markedly Divergent Growth Rates and the Effects of Growth Hormone Treatmenten_US
dc.typeArticleen_US

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