Alterations in hepatic gene expressions of CYP2C11, CYP2C6V, and CYP2D3 enzymes in endotoxemic rats

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dc.contributor.authorOzer, Erdem K.
dc.contributor.authorKurtgoz, Serkan
dc.contributor.authorGoktas, Mustafa T.
dc.contributor.authorKaraca, Ragip O.
dc.contributor.authorCaliskan, Metin
dc.contributor.authorBariskaner, Hulagu
dc.contributor.authorIskit, Alper B.
dc.date.accessioned2020-03-26T19:33:44Z
dc.date.available2020-03-26T19:33:44Z
dc.date.issued2017
dc.departmentSelçuk Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective: Human cytochrome P450 2C9 (CYP2C9), CYP2C19, and CYP2D6 (corresponding to rat CYP2C11, CYP2C6V, and CYP2D3, respectively) are the major enzymes responsible for the metabolism of a wide range of drugs and chemicals. Changes in CYP efficiency are associated with disease susceptibility that can lead to drug toxicity or ineffective therapy. We aimed to examine the effects of lipopolysaccharide (LPS)-induced endotoxemia on gene expressions of hepatic microsomal CYP enzymes in rats. Material and Methods: Male Wistar albino rats were allocated into two subgroups of control and LPS. Saline or LPS (10 mg/kg) of same volume (1 mL/kg) was intraperitoneally (i.p.) injected into rats. After 4 hours, liver tissues were removed. Hepatic mRNA expressions of the CYP enzymes were quantitatively analyzed using real-time polymerase chain reaction (PCR). Results: Hepatic gene expressions of CYP2C11 and CYP2C6V decreased (3.35 and 2.25 fold, respectively) in the endotoxemic rats; however, CYP2D3 expression did not change. Conclusion: Our results revealed that endotoxemia changes CYP2C11-and CYP-2C6V-mediated-drug metabolism. Therefore, drug dosage must be cautiously adjusted in the patients with endotoxemia and sepsis.en_US
dc.description.sponsorshipTurkish Academy of SciencesTurkish Academy of Sciences [EA-TUBA-GEBIP/2001-2-11]en_US
dc.description.sponsorshipIn 2001, Alper B. Iskit, senior author of this article, has been supported by the Turkish Academy of Sciences, in the framework of the Young Scientist Award Program (EA-TUBA-GEBIP/2001-2-11).en_US
dc.identifier.citationÖzer, E. K., Kurtgöz, S., Göktaş, M. T., Karaca, R. Ö., Çalışkan, M., Barışkaner, H., İskit, A. B. (2017). Alterations in Hepatic Gene Expressions of CYP2C11, CYP2C6V, and CYP2D3 Enzymes in Endotoxemic Rats. Journal of Medical and Surgical Intensive Care Medicine, 8(2), 50-53.
dc.identifier.doi10.5152/dcbybd.2017.1552en_US
dc.identifier.endpage53en_US
dc.identifier.issn1309-1689en_US
dc.identifier.issn1309-6222en_US
dc.identifier.issue2en_US
dc.identifier.pmid#YOKen_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage50en_US
dc.identifier.urihttps://dx.doi.org/10.5152/dcbybd.2017.1552
dc.identifier.urihttps://hdl.handle.net/20.500.12395/34774
dc.identifier.volume8en_US
dc.identifier.wosWOS:000424043400004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorOzer, Erdem K.
dc.institutionauthorBariskaner, Hulagu
dc.language.isoenen_US
dc.publisherAVESen_US
dc.relation.ispartofJournal of Medical and Surgical Intensive Care Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectEndotoxemiaen_US
dc.subjectliveren_US
dc.subjectgene expressionsen_US
dc.subjectcytochrome P450 enzymesen_US
dc.titleAlterations in hepatic gene expressions of CYP2C11, CYP2C6V, and CYP2D3 enzymes in endotoxemic ratsen_US
dc.typeArticleen_US

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