Syzgium coriaceum Bosser & J. Gueho-An endemic plant potentiates conventional antibiotics, inhibits clinical enzymes and induces apoptosis in breast cancer cells

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dc.contributor.authorMahomoodally, Mohamad Fawzi
dc.contributor.authorUğurlu, Aslı
dc.contributor.authorLiorent-Martinez, Eulogio J.
dc.contributor.authorNagamootoo, Meenathee
dc.contributor.authorPicot-Allain, Marie Carene Nancy
dc.contributor.authorBaloğlu, Mehmet Cengiz
dc.contributor.authorAltunoğlu, Yasemin Çelik
dc.contributor.authorHosenally, Muzzammil
dc.contributor.authorZengin, Gökhan
dc.date.accessioned2020-03-26T20:20:30Z
dc.date.available2020-03-26T20:20:30Z
dc.date.issued2020
dc.departmentSelçuk Üniversitesi, Fen Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractSyzygium species are renowned for being important reservoirs of phytochemicals with pharmaceutical and biomedical potential. However, no attempt has been made to delineate the pharmacological potential and phytochemical profile of Syzgtturt coriaceum Bosser & J. Gueho, an endemic plant to Mauritius. The present study aimed to determine the antibacterial, antioxidant, cytotoxicity, enzyme inhibitory and phytochemical profile of the ethyl acetate and methanol extracts of S. coriaceum. Preliminary qualitative phytochemical study of the extracts showed the presence of phenol, tannins, and alkaloids. Chemical characterisation showed the presence of derivatives of tannins, gallic acids, quercetin, and kaempferol. Potentiating activity between S. coriaceum extracts and antibiotics (ampicillin and streptomycin) using the checkerboard method showed additive interaction. The extracts showed potent 2,2-diphenyl-1-picrylhydrazyl (DPPH) (2.95 and 2.93 mmol trolox equivalent (TE)/g sample for ethyl acetate and methanol extracts, respectively) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid (ABTS) (4.09 and 3.83 mmol TE/g sample for ethyl acetate and methanol extracts, respectively) scavenging abilities. Syzygium coriaceum extracts were active inhibitors of alpha-glucosidase (about 47 mmol acarbose equivalent/g sample for ethyl acetate and methanol extract). S. coriaceum methanol extract caused maximum inhibition against human breast adenocarcinoma (MDA-MB-231) cancer cells after 48 h treatment with the IC50 value of 53.41 mu g/mL. Expression of anti-apoptotic Bcl2 and BIRCS genes were down-regulated. It can be concluded that S. coriaceum extracts lead to YIDA-MB-231 cells apoptosis. This investigation has provided a comprehensive report of the biological and chemical profile of S. coriaceum. Collected scientific evidences can open new avenues for research and contributes towards establishing primary data on Syzygium species endemic to Mauritius for bioprospection of novel phytopharmaceuticals.en_US
dc.identifier.citationMahomoodally, M. F., Uğurlu, A., Liorent-Martinez, E. J., Nagamootoo, M., Picot-Allain, M. C. N., Baloğlu, M. C., Altunoğlu, Y. C., Hosenally, M., Zengin, G. (2020). Syzgium coriaceum Bosser & J. Guého: An Endemic Plant Potentiates Conventional Antibiotics, Inhibits Clinical Enzymes and Induces Apoptosis in Breast Cancer Cells. Industrial Crops & Products, 143, 1-12.
dc.identifier.doi10.1016/j.indcrop.2019.111948en_US
dc.identifier.issn0926-6690en_US
dc.identifier.issn1872-633Xen_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.indcrop.2019.111948
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38603
dc.identifier.volume143en_US
dc.identifier.wosWOS:000503323200026en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorZengin, Gökhan
dc.language.isoenen_US
dc.publisherELSEVIERen_US
dc.relation.ispartofINDUSTRIAL CROPS AND PRODUCTSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectPhytochemicalen_US
dc.subjectApoptosisen_US
dc.subjectAntioxidanten_US
dc.subjectEnzymeen_US
dc.subjectCheckerboarden_US
dc.subjectCytotoxicityen_US
dc.titleSyzgium coriaceum Bosser & J. Gueho-An endemic plant potentiates conventional antibiotics, inhibits clinical enzymes and induces apoptosis in breast cancer cellsen_US
dc.typeArticleen_US

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