Increased serum interleukin-33 levels in patients with Graves' disease

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dc.contributor.authorÇelik, Hüseyin Tuğrul
dc.contributor.authorAbuşoğlu, Sedat
dc.contributor.authorBurnik, Ferda Sevimli
dc.contributor.authorSezer, Sevilay
dc.contributor.authorSerdar, Muhittin Abdulkadir
dc.contributor.authorErcan, Müjgan
dc.contributor.authorUğuz, Nihal
dc.contributor.authorAvcıküçük, Mehmet
dc.contributor.authorBal, Ceylan
dc.contributor.authorYıldırımkaya, M.
dc.date.accessioned2020-03-26T18:48:15Z
dc.date.available2020-03-26T18:48:15Z
dc.date.issued2013
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractobjective. Interleukin-33 (IL-33), a 30 kDa cytokine, is a member of IL-1 family. It is considered to be an autoimmune biomarker associated with T helper 2 (T 2) response. ?-interferon is also produced by T helper 1 (T 1) cells to induce cellular responses. ?-interferon is a 143-amino acid residue glycoprotein with several biological functions including potent anti-viral activity, stimulation of macrophage activity, modulation of Major Histocompatibilty Complex class I/class II expression, and regulation of a diversity of specific immune responses. Te aim of this study was to investigate the serum levels of IL-33 and ?-interferon in different thyroid disorders. Methods. Twenty patients with Graves' disease, 21 patients with Hashimoto hypothyroidism, 21 euthyroid Hashimoto patients, and 27 control subjects were recruited to this study. Blood samples were drawn and IL-33 and ?-interferon tests were analyzed from 89 participants. Serum IL-33 and ?-interferon analyses were performed by enzyme-linked immunosorbent assay. results. Tere was no statistically significant difference between groups for serum ?-interferon levels. Serum IL-33 concentrations were significantly higher in Graves' disease group compared to the other groups (p<0.000) There was a positive correlation between serum IL-33 and free triiodothyronine (fT3) and thyroxine (fT4). Also, negative correlation between serum IL-33 and thyroid-stimulating hormone (TSH) was statistically significant (p<0.000). Conclusions. Te correlation of serum IL-33 with thyroid hormone levels may be a useful indicator for Graves' disease. These findings may help to make evident the pathophysiologic processes of the autoimmune thyroid diseases and improve therapeutic methods.en_US
dc.identifier.doi10.4149/endo_2013_02_57en_US
dc.identifier.endpage64en_US
dc.identifier.issn1210-0668en_US
dc.identifier.issue2en_US
dc.identifier.pmid23641786en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage57en_US
dc.identifier.urihttps://dx.doi.org/10.4149/endo_2013_02_57
dc.identifier.urihttps://hdl.handle.net/20.500.12395/30163
dc.identifier.volume47en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofEndocrine Regulationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCytokinesen_US
dc.subjectHashimoto thyroiditisen_US
dc.subjectHyperthyroiditisen_US
dc.subjectInterleukinen_US
dc.subjectThyroid disordersen_US
dc.titleIncreased serum interleukin-33 levels in patients with Graves' diseaseen_US
dc.typeArticleen_US

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