Evaluation of acute phase proteins and cytokines in dogs with parvoviral enteritis
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Dosyalar
Tarih
2015
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Selçuk Ünivesitesi Veterinerlik Fakültesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Bu çalışmanın amacı parvoviral enteritli köpeklerde akut faz proteinler ve sitokinlerdeki değişimleri değerlendirmektir. Gereç ve Yöntem: Çalışmanın materyalini 2 - 8 aylık 46 parvoviral enteritli (PVE grubu) ve 8 sağlıklı (Kontrol grup) köpek oluşturdu. Pravoviral enteritli köpeklerde anoreksi, ateş, depresyon, uyuşukluk, kusma ve kanlı ishal belirlendi. Köpeklerde parvoviral enteritis teşhisi dışkı parvovirüs antijen testi ile doğrulandı. Parvoviral enteritis teşhisi konulan köpeklerden kan örnekleri alınarak serum interlökin 1ß (IL-1ß), tümör nekrozis faktör alfa (TNF-?), gama interferon (INF-?), C-reaktif protein (CRP), serum amiloid A (SAA), fibrinojen ve protein C (PC) düzeyleri ELISA metoduyla ölçüldü. Bulgular: Sağlıklı grupla karşılaştırıldığında, parvoviral enteritli köpeklerin serum IL-1ß, TNF-?, INF-?, CRP, SAA, fibrinojen ve PC seviyelerinde istatistiksel olarak önemli artışlar belirlendi. Öneri: Parvoviral enteritisli köpeklerde serum IL-1ß, TNF-?, INF-?, CRP, SAA, fibrinojen ve PC seviyelerinde artışların belirlenmesi yangının değerlenmesinde faydalı olacağı ifade edilebilir.
Aim: The aim of the present study was to evaluate the alterations in acute phase proteins and cytokines in dogs with parvoviral enteritis. Materials and Methods: Aged between 2 - 8 moths, fortysix dogs with parvoviral enteritis (PVE group) and 8 healthy dogs (Control group) were as material in this study. Anorexia, fever, depression, lethargy, vomiting and hemorrhagic diarrhea were determined in the dogs with parvoviral enteritis. Parvovirus infection in dogs was confirmed by examining faeces via parvovirus antigen test. Blood samples were collected from all dogs. Serum interleukin-1ß (IL-1ß), tumor necrosis factor alpha (TNF-?), interferon-? (INF-?), C-reactive protein (CRP), serum amyloid A (SAA), fibrinogen and protein C (PC) concentrations were measured by ELISA. Results: Serum IL-1ß, TNF-?, INF-?, CRP, SAA, fibrinogen and PC concentrations were statistically significantly increased in the dogs with parvoviral enteritis compared to control group. Conclusion: It may be stated that increased serum IL-1ß, TNF-?, INF-?, CRP, SAA, fibrinogen and PC concentrations may be useful in assessing the inflammation in canine parvovirus infection.
Aim: The aim of the present study was to evaluate the alterations in acute phase proteins and cytokines in dogs with parvoviral enteritis. Materials and Methods: Aged between 2 - 8 moths, fortysix dogs with parvoviral enteritis (PVE group) and 8 healthy dogs (Control group) were as material in this study. Anorexia, fever, depression, lethargy, vomiting and hemorrhagic diarrhea were determined in the dogs with parvoviral enteritis. Parvovirus infection in dogs was confirmed by examining faeces via parvovirus antigen test. Blood samples were collected from all dogs. Serum interleukin-1ß (IL-1ß), tumor necrosis factor alpha (TNF-?), interferon-? (INF-?), C-reactive protein (CRP), serum amyloid A (SAA), fibrinogen and protein C (PC) concentrations were measured by ELISA. Results: Serum IL-1ß, TNF-?, INF-?, CRP, SAA, fibrinogen and PC concentrations were statistically significantly increased in the dogs with parvoviral enteritis compared to control group. Conclusion: It may be stated that increased serum IL-1ß, TNF-?, INF-?, CRP, SAA, fibrinogen and PC concentrations may be useful in assessing the inflammation in canine parvovirus infection.
Açıklama
Anahtar Kelimeler
Köpek, parvoviral enteritis, akut faz proteinler, sitokinler, Dog, parvoviral enteritis, acute phase protein, cytokines
Kaynak
Eurasian Journal of Veterinary Sciences
WoS Q Değeri
Scopus Q Değeri
Cilt
31
Sayı
3
Künye
Ok, M., Er, C., Yıldız, R., (2015). Evaluation of acute phase proteins and cytokines in dogs with parvoviral enteritis. Eurasian Journal of Veterinary Sciences, 31 (3), 143-147. DOI:10.15312/EurasianJVetSci.2015310970
