The effect of thyroid dysfunction and treatment on fat tissue adiponectin levels in rats

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dc.contributor.authorAtici, Emine.
dc.contributor.authorMogulkoc, Rasim.
dc.contributor.authorBaltaci, Abdulkerim Kasim.
dc.contributor.authorMenevse, Esma.
dc.date.accessioned2020-03-26T20:19:26Z
dc.date.available2020-03-26T20:19:26Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractAdipose tissue is a hormonal active system that produces and releases leptin, adiponectin and resistin. Seen from this aspect, it may be thought that adiponectin may interact with the thyroid axis. Thyroid function disturbance led to changes on the body weight, muscle volume and adipose tissue. Experimental findings show that adiponectin and thyroid hormones have biological interactin with each other. However, various results have been reported a relationship between thyroid hormones and adiponection levels. The aim of the present study was to determine adipose tissue adiponectin levels in rats with thyroid dysfunction and after treatment. Study was performed on 40 Sprague-Dawley male rats. Groups were designed as 1-control, 2-hypothyroidism (Hypo), 3-hypothyroidism + Thyroxine, 4-hyperthyroidism (Hyper), 5-hyperthyroidism + PTU. At the end of 3 weeks experimental period, adipose tissues of rats were analyed for adiponection by Elisa. Experimental hypothyroidism reduced adipose tissue adiponectin levels, but hyperthyrodism increased. Treatment of hypothyroidism and hyperthyroidism corrected disrupted adiponectin levels to control. The results of the present study show that experimental thyroid dysfunction has affected adipose tissue adiponection levels in rats.en_US
dc.description.sponsorshipSelcuk University, Scientific Research CouncilSelcuk University [14202034]en_US
dc.description.sponsorshipThis study was supported by a grant Selcuk University, Scientific Research Council (Grant number is 14202034).en_US
dc.identifier.citationAtici, E., Mogulkoc, R., Baltaci, A. K., Menevse, E. (2019). The Effect of Thyroid Dysfunction and Treatment on Fat Tissue Adiponectin Levels in Rats. Biointerface Research in Applied Chemistry, 9(1), 3790-3793.
dc.identifier.doi10.33263/BRIAC91.790793en_US
dc.identifier.endpage3793en_US
dc.identifier.issn2069-5837en_US
dc.identifier.issue1en_US
dc.identifier.pmid#YOKen_US
dc.identifier.startpage3790en_US
dc.identifier.urihttps://dx.doi.org/10.33263/BRIAC91.790793
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38267
dc.identifier.volume9en_US
dc.identifier.wosWOS:000459375100003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.institutionauthorMogulkoc, Rasim.
dc.institutionauthorBaltaci, Abdulkerim Kasim.
dc.language.isoenen_US
dc.publisherBIOINTERFACE RESEARCH APPLIED CHEMISTRYen_US
dc.relation.ispartofBIOINTERFACE RESEARCH IN APPLIED CHEMISTRYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjecthypothyroidismen_US
dc.subjecthyperthyroidismen_US
dc.subjectadiponectinen_US
dc.subjectraten_US
dc.titleThe effect of thyroid dysfunction and treatment on fat tissue adiponectin levels in ratsen_US
dc.typeArticleen_US

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