Should We Routinely Screen for Warfarin Gene Polymorphism in Patients with Coumadin Overdose?
Küçük Resim Yok
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
AVES
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Genetic polymorphisms can affect an individual's response to the pharmacological agents. Warfarin has a narrow therapeutic range and dose arrangement may vary from individual to individual. An insufficient dose may fail to prevent thromboembolism and overdose may increase the risk of bleeding. Increasing evidence suggests that genetic variation of CYP2C9 and VKORC1 greatly influences effective warfarin dosing (1). In the present case report, frequently occurring warfarin toxicity was caused by a genetic mutation in the patient with mitral valve replacement.
Açıklama
Anahtar Kelimeler
warfarin, genetic, CYP2C9, VKORC1
Kaynak
EURASIAN JOURNAL OF EMERGENCY MEDICINE
WoS Q Değeri
N/A
Scopus Q Değeri
Cilt
15
Sayı
4
