The effects of three different prokinetic drugs on the motility hormones level in lambs with postoperative ileus

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dc.contributor.authorAltan, Semih
dc.contributor.authorDonmez, Kaan
dc.contributor.authorAltan, Feray
dc.contributor.authorAlkan, Fahrettin
dc.date.accessioned2020-03-26T19:56:14Z
dc.date.available2020-03-26T19:56:14Z
dc.date.issued2018
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe aim of this study was to evaluate the effects of the three different prokinetic agents, namely erythromycin, lidocaine, and metoclopramide in lambs with postoperative ileus (POI) using motilin and ghrelin, which are known as motility markers. Twenty lambs were allocated to 4 groups of 5 lambs each. An enterotomy was performed on the ileum of each lamb. Erythromycin (8.8 mg/ kg), metoclopramide (0.2 mg/kg), and saline (2 mL) were administered as single dose IM before surgery in the ERT, MET, and CNTR groups, respectively. Lidocaine was administered to the LID group, both as a bolus before (1.3 mg/kg IV) and as a continuous rate infusion during surgery (0.05 mg/kg/h IV). Serwn motilin and ghrelin concentrations as motility hormones were measured with ELISA. The serum motilin concentration was significantly higher at 0, 1, 3, 5, 10, 24, and 48 h in the ERT group and at 1 and 10 h in the LID group. The serum ghrelin concentration was significantly higher at 0, 1, and 48 h in the ERT group and at 3, 5, 10, 24, and 48 h in the LID group. As a result, erythromycin and lidocaine was thought to be useful in lambs with POI according to the stimulatory effects on the motility hormones.en_US
dc.description.sponsorshipScientific Research Council of Dicle UniversityDicle University [Veteriner.15.002]en_US
dc.description.sponsorshipThis research was financially supported by the Scientific Research Council of Dicle University (Project No: Veteriner.15.002) and a part of this study was presented as a poster presentation in IVEK's 3rd International Convention of Pharmaceuticals and Pharmacies Congress in Istanbul/Turkey between 26-29 April 2017.en_US
dc.identifier.doi10.3906/vet-1803-3en_US
dc.identifier.endpage440en_US
dc.identifier.issn1300-0128en_US
dc.identifier.issue5en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage435en_US
dc.identifier.urihttps://dx.doi.org/10.3906/vet-1803-3
dc.identifier.urihttps://hdl.handle.net/20.500.12395/37031
dc.identifier.volume42en_US
dc.identifier.wosWOS:000447163600010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSCIENTIFIC TECHNICAL RESEARCH COUNCIL TURKEY-TUBITAKen_US
dc.relation.ispartofTURKISH JOURNAL OF VETERINARY & ANIMAL SCIENCESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectGhrelinen_US
dc.subjectmotilinen_US
dc.subjectpostoperative ileusen_US
dc.subjectlamben_US
dc.titleThe effects of three different prokinetic drugs on the motility hormones level in lambs with postoperative ileusen_US
dc.typeArticleen_US

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