Effect of Recombinant-Human-Erythropoietin (Rhuepo) Therapy on Plasma FT(3), FT(4), TSH, FSH, LH, Free Testesterone and Prolactin Levels in Hemodialysis-Patients

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dc.contributor.authorYeksan, M.
dc.contributor.authorTamer, Nour
dc.contributor.authorCirit, Mustafa
dc.contributor.authorTürk, Süleyman
dc.contributor.authorAkhan, Galip
dc.contributor.authorAkkuş, İdris
dc.contributor.authorErkul, I.
dc.date.accessioned2020-03-26T16:24:16Z
dc.date.available2020-03-26T16:24:16Z
dc.date.issued1992
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe aim of this study was to evaluate the effect of r-HuEPO treatment on free triiodothyronine (FT3), free thyroxine (FT4), thyroid stimulating hormone (TSH), follicle-stimulating hormone (FSH), luteinizing hormone (LH), free testosterone and prolactin levels in uremic hemodialysis patients. Twenty-four uremic hemodialysis patients were given r-HuEPO with a dose 60 U/kg as intravenous bolus injection at the end of each dialysis session. Once the hematocrit value of the patient had reached a range of 30-35%, the dose was adjusted so as to keep the hematocrit levels constant. Twenty uremic dialysis patients were taken as control group. The above-mentioned hormone levels of patients and control group were determined before and 4 months after r-HuEPO treatment. After the treatment, serum prolactin levels significantly decreased in both sexes (36.8 +/- 7.8 vs 22.9 +/- 6.3 ng/ml and 78.3 +/-13.3 vs 37.4 +/- 10.4 ng/ml male and female, respectively). FT3 and FT4 significantly increased (1.17 vs 1.67 pg/ml, p<0.05, and 0.64 vs 0.084 ng/dl, p<0.05, respectively). TSH levels increased but those changes were not significant. There was no change in the level of any hormone in the control group. Also, the sexual functions of eight male patients treated with r-HuEPO improved and menstruation started again in four female patients. We concluded that r-HuEPO treatment especially decreases prolactin level in uremic hemodialysis patients. It is conceivable that correction of elevated prolactin levels could improve sexual disorders in these patients.en_US
dc.identifier.citationYeksan, M., Tamer, N., Cirit, M., Türk, S., Akhan, G., Akkuş, I., Erkul, I., (1992). Effect of Recombinant-Human-Erythropoietin (Rhuepo) Therapy on Plasma FT(3), FT(4), TSH, FSH, LH, Free Testesterone and Prolactin Levels in Hemodialysis-Patients. International Journal of Artificial Organs, 15(10), 585-589.
dc.identifier.endpage589en_US
dc.identifier.issn0391-3988en_US
dc.identifier.issue10en_US
dc.identifier.pmid1428205en_US
dc.identifier.startpage585en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/16137
dc.identifier.volume15en_US
dc.identifier.wosWOS:A1992JW88100003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWICHTIG EDITOREen_US
dc.relation.ispartofInternational Journal of Artificial Organsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectRECOMBINANT HUMAN ERYTHROPOIETINen_US
dc.subjectUREMIAen_US
dc.subjectPROLACTINen_US
dc.subjectFT(3)en_US
dc.subjectFT(4)en_US
dc.subjectTSHen_US
dc.subjectFSHen_US
dc.subjectLHen_US
dc.subjectFREE TESTOSTERONEen_US
dc.titleEffect of Recombinant-Human-Erythropoietin (Rhuepo) Therapy on Plasma FT(3), FT(4), TSH, FSH, LH, Free Testesterone and Prolactin Levels in Hemodialysis-Patientsen_US
dc.typeArticleen_US

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