Apoptosis: an underlying factor for accelerated periodontal disease associated with diabetes in rats

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dc.contributor.authorTunali, Mustafa
dc.contributor.authorAtaoglu, Tamer
dc.contributor.authorCelik, Ilhami
dc.date.accessioned2020-03-26T18:49:25Z
dc.date.available2020-03-26T18:49:25Z
dc.date.issued2014
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractDiabetes mellitus (DM) is well-established risk factor for periodontal disease. DM can also lead to changes in the number of apoptotic cells in periodontal tissues. The goal of this study was to evaluate apoptosis, depending on DM, in healthy and diseased periodontal soft tissues. A total of 43 adult male Sprague-Dawley rats were used in this study. Experimental periodontitis was created by placing silk ligatures around the cervices of the first mandibular molars. Experimental diabetes was induced by intraperitoneal injection of the diabetogenic agent streptozotocin (STZ). Following the induction of both experimental diseases, the animals were divided into four groups: (1) The healthy group (H) (n = 10); (2) The diabetes group (D) (n = 10); (3) The periodontitis group (P) (n = 11); and (4) The diabetes and periodontitis group (DP) (n = 12). Apoptotic cells were determined by immunohistochemistry, and the frequency of apoptotic cells was evaluated by apoptotic index score. It was observed that there was less apoptosis in both the epithelial and gingival connective tissue cells of healthy diabetic tissues than in healthy tissues without diabetes. When periodontal disease existed, apoptosis increased in both the epithelial and gingival connective tissues of diabetic and non-diabetic animals. There may be differences in the apoptotic mechanisms in the periodontal soft tissues of diabetic and non-diabetic animals. Apoptosis may be one of the underlying factors in increased risk for periodontal disease that is associated with diabetes.en_US
dc.description.sponsorshipScientific Research Project Coordination Center of Selcuk UniversitySelcuk Universityen_US
dc.description.sponsorshipThis study was supported by Scientific Research Project Coordination Center of Selcuk University.en_US
dc.identifier.doi10.1007/s00784-013-1158-1en_US
dc.identifier.endpage1833en_US
dc.identifier.issn1432-6981en_US
dc.identifier.issn1436-3771en_US
dc.identifier.issue7en_US
dc.identifier.pmid24317877en_US
dc.identifier.startpage1825en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s00784-013-1158-1
dc.identifier.urihttps://hdl.handle.net/20.500.12395/30606
dc.identifier.volume18en_US
dc.identifier.wosWOS:000341417400015en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSPRINGER HEIDELBERGen_US
dc.relation.ispartofCLINICAL ORAL INVESTIGATIONSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAnimal modelen_US
dc.subjectDiabetesen_US
dc.subjectPeriodontal diseaseen_US
dc.subjectEpitheliumen_US
dc.subjectConnective tissueen_US
dc.titleApoptosis: an underlying factor for accelerated periodontal disease associated with diabetes in ratsen_US
dc.typeArticleen_US

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