Metabolomics profiling, bio-pharmaceutical properties of Hypericum lanuginosum extracts by in vitro and in silico approaches

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dc.contributor.authorMahomoodally, Mohamad Fawzi
dc.contributor.authorZengin, Gökhan
dc.contributor.authorZheleva-Dimitrova, Dimitrina
dc.contributor.authorMollica, Adriano
dc.contributor.authorStefanucci, Azzurra
dc.contributor.authorSinan, Kouadio Ibrahime
dc.contributor.authorAumeeruddy, Muhammad Zakariyyah
dc.date.accessioned2020-03-26T20:15:11Z
dc.date.available2020-03-26T20:15:11Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Fen Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractHypericum species are important as a source of natural-bioactive compounds in the Turkish folk medicine. Among them, Hypericum lanuginosum has not been explored so far for its biological properties. The current study aimed to determine the antioxidant activity, enzyme inhibitory potential, and phenolic content (spectrophotometric and liquid chromatography/high resolution mass spectrometry (LC-HRMS) analysis) of different solvent extracts (ethyl acetate, methanol, and aqueous) of H. lanuginosum aerial parts. Twenty one phenolic compounds including phenolic acids, acylquinic acids, flavonoids and bioflavonoids were identified by LC-HRMS profiles. Quinic acid was the dominant compound in all H. lanuginosum extracts. The highest total phenolic (168.56 mg gallic acid equivalent (GAE)) and flavonoid (53.22 mg rutin equivalent (RE)) contents were observed in the aqueous extract. Also, the aqueous extract was the best antioxidant, showing the highest 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline)-6-sulfonic acid (ABTS) scavenging, ferric reducing antioxidant power (FRAP), cupric reducing antioxidant capacity (CUPRAC), and activity in the phosphomolybdenum assay. The methanol extract exhibited the strongest metal chelating and inhibitory effect on alpha-amylase and tyrosinase. In contrast, the most efficient inhibitor of cholinesterases and alpha-glucosidase was the ethyl acetate extract. Docking showed that the selected compounds are all possible inhibitor candidates of tyrosinase. To conclude, each solvent extract of H. lanuginosum varied in its chemical and biological profile but overall, possess a good source of many natural agents which can be used to manage ailments inked with oxidative stress.en_US
dc.identifier.citationMahomoodally, M. F., Zengin, G., Zheleva-Dimitrova, D., Mollica, A., Stefanucci, A., Sinan, K. I., Aumeeruddy, M. Z. (2019). Metabolomics Profiling, Bio-Pharmaceutical Properties of Hypericum Lanuginosum Extracts by in vitro and in silico Approaches. Industrial Crops and Products, 133, 373-382.
dc.identifier.doi10.1016/j.indcrop.2019.03.033en_US
dc.identifier.endpage382en_US
dc.identifier.issn0926-6690en_US
dc.identifier.issn1872-633Xen_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage373en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.indcrop.2019.03.033
dc.identifier.urihttps://hdl.handle.net/20.500.12395/37996
dc.identifier.volume133en_US
dc.identifier.wosWOS:000466250000043en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorZengin, Gökhan
dc.institutionauthorSinan, Kouadio Ibrahime
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.relation.ispartofINDUSTRIAL CROPS AND PRODUCTSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectDockingen_US
dc.subjectAntioxidanten_US
dc.subjectEnzyme inhibitionen_US
dc.subjectPhenolicen_US
dc.subjectTyrosinaseen_US
dc.subjectLC-HRMSen_US
dc.titleMetabolomics profiling, bio-pharmaceutical properties of Hypericum lanuginosum extracts by in vitro and in silico approachesen_US
dc.typeArticleen_US

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