Efficacies of Free and Liposome-Encapsulated Enrofloxacin (Baytril (R)) Against Staphylococcus Aureus Infection in Turkish Shepherd Dog Neutrophils in Vitro

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dc.contributor.authorBaş, A. L.
dc.contributor.authorElmas, M.
dc.contributor.authorŞimşek, A.
dc.contributor.authorTraş, B.
dc.contributor.authorYazar, E.
dc.contributor.authorHadimli, H. H.
dc.date.accessioned2020-03-26T16:36:15Z
dc.date.available2020-03-26T16:36:15Z
dc.date.issued2000
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe influence of free and liposome-encapsulated enrofloxacin at concentrations of 1, 2 and 4 mu g/ml was studied on phagocytic and intracellular killing of Staphylococcus aureus, in cultured neutrophils of six healthy Turkish Shepherd Dogs. Enrofloxacin was encapsulated by using reverse-phase evaporation method in multilamellar liposomes composed of 15 mg egg phosphatidylcholine and 35 mg cholesterol. Phagocytic and killing activity of neutrophils were determined by fluorescent microscopic technique. Liposome-encapsulated enrofloxacin significantly enhanced the intraphagocytic killing of bacteria in neutrophils compared to free drug. Phagocytic activity of neutrophils was not significantly different among groups. The results obtained in the present study show that use of enrofloxacin encapsulated in liposomes may improve the antibacterial efficacy of the antibiotic.en_US
dc.description.abstractL’activité bactéricide des neutrophiles de chiens de berger turcs, traités par l'enrofloxacine et par l'enrofloxacine encapsulée vis-à-vis de Staphylococcus aureus fait l’objet de cette étude. La phagocytose et l’activité bactéricide des neutrophiles ont été évaluées par fluorescence. L'enrofloxacine encapsulée augmente le pouvoir bactéricide de l’enrofloxacine, alors que l’activité phagocytaire n’est pas modifiée. Ces résultats montrent une meilleure efficacité de l’enrofloxacine encapsulée.
dc.identifier.citationHadimli, H. H., Yazar, E., Traş, B., Şimşek, A., Elmas, M., Baş, A. L., (2000). Efficacies of Free and Liposome-Encapsulated Enrofloxacin (Baytril (R)) Against Staphylococcus Aureus Infection in Turkish Shepherd Dog Neutrophils in Vitro. Revue De Medecine Veterinaire, 151(5), 415-420.
dc.identifier.endpage420en_US
dc.identifier.issn0035-1555en_US
dc.identifier.issue5en_US
dc.identifier.startpage415en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/17211
dc.identifier.volume151en_US
dc.identifier.wosWOS:000087999200004en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.institutionauthorBaş, A. L.
dc.institutionauthorElmas, M.
dc.institutionauthorTraş, B.
dc.institutionauthorYazar, E.
dc.language.isoenen_US
dc.publisherEcole National Vet Toulouseen_US
dc.relation.ispartofRevue De Medecine Veterinaireen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectenrofloxacinen_US
dc.subjectintracellular bioactivityen_US
dc.subjectneutrophileen_US
dc.subjectStaphylococcus aureusen_US
dc.subjectTurkish Shepherd Dogen_US
dc.subjectliposome
dc.subjectneutrophile
dc.titleEfficacies of Free and Liposome-Encapsulated Enrofloxacin (Baytril (R)) Against Staphylococcus Aureus Infection in Turkish Shepherd Dog Neutrophils in Vitroen_US
dc.title.alternativeEfficacité in Vitro De L'enrofloxacine Et De L'enrofloxacine Encapsulée (Baytril®) Vis-à-vis De L'infection Des Neutrophiles Par Staphylococcus Aureus Chez Le Chien De Berger Turcen_US
dc.typeArticleen_US

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