Exploring the therapeutic potential and phenolic composition of two Turkish ethnomedicinal plants - Ajuga orientalis L. and Arnebia densiflora (Nordm.), Cheek for updates Ledeb.

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dc.contributor.authorZengin, Gökhan
dc.contributor.authorCeylan, Ramazan
dc.contributor.authorKatanic, Jelena
dc.contributor.authorAktümsek, Abdurrahman
dc.contributor.authorMatic, Sanja
dc.contributor.authorBoroja, Tatjana
dc.contributor.authorStanic, Snezana
dc.date.accessioned2020-03-26T19:53:57Z
dc.date.available2020-03-26T19:53:57Z
dc.date.issued2018
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractAjuga orientalis L. and Arnebia densiflora (Nordm.) Ledeb. are plants traditionally used in Turkish ethnomedicine to manage common ailments. Nonetheless, there is currently a dearth of investigations geared towards highlighting the inhibitory properties of A. orientalis and A. densiliora against key carbohydrate hydrolyzing enzymes (alpha-amylase and alpha-glucosidase), tyrosinase, and cholinesterases (acetylcholinesterase and butyrylcholinesterase) involved in diabetes, post inflammatory hyperpigmentation, and neurodegenerative diseases, respectively. We aimed to shed light on the antioxidant potential and various enzymatic inhibitory properties of tested methanolic extracts of these plants. In vitro antioxidant activity, DNA protective effects, antimicrobial activity (against 8 bacteria, 10 fungal strains and 1 yeast), as well as phenolic compounds determination and HPLC (high performance liquid chromatography) analysis were performed. 17 phenolic components were quantified in tested extracts. Major phenolic compounds present in A. orientalis extract were chlorogenic acid, benzoic acid, and luteolin. A. densiflora extract revealed the presence of gallic acid, rutin, rosmarinic acid, quercetin, luteolin, and apigenin. A. densiflora showed a stronger antioxidant capacity, higher total phenolic (33.72 mg GAE/g), and total flavonoid contents (55.93 mgRE/g), as well as protection of DNA against hydroxyl radical compared to A. orientalis extract. The tested extracts showed similar antimicrobial activity with low effect against the bacterial and fungal strains. The tested extracts showed a slightly higher potential to inhibit tyrosinase activity, while inhibition of the activity of the other examined enzymes by the extracts was weak. The observed biological activities and presence of bioactive phytochemicals can open new perspectives to develop novel dietetic supple. ments.en_US
dc.description.sponsorshipMinistry of Education, Science and Technological Development of the Republic of Serbia [III43004, III41010.]en_US
dc.description.sponsorshipPart of this study was supported by the Ministry of Education, Science and Technological Development of the Republic of Serbia, Grants No. III43004 and III41010.en_US
dc.identifier.doi10.1016/j.indcrop.2018.02.054en_US
dc.identifier.endpage248en_US
dc.identifier.issn0926-6690en_US
dc.identifier.issn1872-633Xen_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage240en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.indcrop.2018.02.054
dc.identifier.urihttps://hdl.handle.net/20.500.12395/36627
dc.identifier.volume116en_US
dc.identifier.wosWOS:000429506000028en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.relation.ispartofINDUSTRIAL CROPS AND PRODUCTSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCholinesteraseen_US
dc.subjectAmylaseen_US
dc.subjectGlucosidaseen_US
dc.subjectPhytochemicalen_US
dc.subjectBioactivityen_US
dc.subjectAntimicrobialen_US
dc.titleExploring the therapeutic potential and phenolic composition of two Turkish ethnomedicinal plants - Ajuga orientalis L. and Arnebia densiflora (Nordm.), Cheek for updates Ledeb.en_US
dc.typeArticleen_US

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