LC-MS, NMR fingerprint of Potentilla argentea and Potentilla recta extracts and their in vitro biopharmaceutical assessment

Basit Öğe Kaydı
dc.contributor.authorSut, Stefania
dc.contributor.authorDall'Acqua, Stefano
dc.contributor.authorUysal, Şengül
dc.contributor.authorZengin, Gökhan
dc.contributor.authorAktümsek, Abdurrahman
dc.contributor.authorPicot-Allain, Caren
dc.contributor.authorMahomoodally, Mohamad Fawzi
dc.date.accessioned2020-03-26T20:15:02Z
dc.date.available2020-03-26T20:15:02Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Fen Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractMany Potentilla species are used as traditional drugs in several countries and also studied for their possible therapeutic properties. As part of our continuous effort to shed light on the biopharmaceutical potential of such plant species, this study was aimed to establish the phytochemical fingerprinting and to evaluate biopharmaceutical potential of methanol, ethyl acetate, and water extracts obtained from the aerial parts of Potentilla recta L. and P. argentea L Combination of 1 dimension, 2 dimension-nuclear magnetic resonance as well as LC-DAD-ESI-MS and LC-APCI-MS allowed the identification of ellagitannins, flavonol glycosides, and triterpene constituents. To quantify different constituents in the extracts obtained with different solvents, the total contents in phenolics, flavonoids, saponins, and triterpenoid were evaluated. The antioxidant activity was assessed by the means of metal chelation, phosphomolybdenum, radical quenching (by 2,2-dipheny1-1-picrylhydrazyl [DPPFI] and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid)[ABTS]) and reduction ability (by cupric reducing antioxidant capacity [CUPRAC] and ferric reducing antioxidant power [FRAP]) assays. Phytochemical analysis showed similar composition of the tested methanol extracts. Acetylcholinesterase (AChE), butyrylcholinesterase (BChE), tyrosinase, alpha-amylase, and alpha-glucosidase were selected as target enzymes to detect enzyme inhibitory potentials of these extracts. The water extract of P. argentea (113.29 mg gallic acid equivalent/g extract) contained the highest phenolic amount while the methanol extract (519.70 mg quillaja equivalent/g extract) showed the highest saponin content. The water extract of both Potentilla species was the most potent ARTS scavenger as well as present the highest CUPRAC activity. The most potent inhibitory activity against AChE and BChE was observed for the ethyl acetate extracts of P. recta and P. argentea. The methanol extracts of P. recta (53.16 mmol acarbose equivalent [ACAS]/g extract) and P. argentea (45.68 mmol ACAE/g extract) were the most active inhibitors of alpha-glucosidase. Data collected from this study support the multiple therapeutic actions of P. recta and P. argentea and justify further pharmacological investigations for potential applications in the pharmaceutical industry.en_US
dc.identifier.citationSut, S., Dall’Acqua, S., Uysal, S., Zengin, G., Aktümsek, A., Picot-Allain, C., Mahomoodally, F. (2019). LC-MS, NMR Fingerprint of Potentilla argentea and Potentilla recta Extracts and Their in vitro Biopharmaceutical Assessment. Industrial Crops and Products, 131, 125-133.
dc.identifier.doi10.1016/j.indcrop.2019.01.047en_US
dc.identifier.endpage133en_US
dc.identifier.issn0926-6690en_US
dc.identifier.issn1872-633Xen_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage125en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.indcrop.2019.01.047
dc.identifier.urihttps://hdl.handle.net/20.500.12395/37973
dc.identifier.volume131en_US
dc.identifier.wosWOS:000460991700016en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorUysal, Şengül
dc.institutionauthorZengin, Gökhan
dc.institutionauthorAktümsek, Abdurrahman
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.relation.ispartofINDUSTRIAL CROPS AND PRODUCTSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectPotentillaen_US
dc.subjectEllagitannisen_US
dc.subjectTriterpenoidsen_US
dc.subjectAntioxidanten_US
dc.subjectEnzymesen_US
dc.subjectPhyto-pharmaceuticsen_US
dc.titleLC-MS, NMR fingerprint of Potentilla argentea and Potentilla recta extracts and their in vitro biopharmaceutical assessmenten_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Stefania SUT.pdf
Boyut:
1.5 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Full Text Access
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Biyoloji/Makale Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu