The preventive effect of diphenhydramine on bacterial growth in propofol: A laboratory study

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dc.contributor.authorGüzelant A.
dc.contributor.authorApiliogullari S.
dc.contributor.authorKara I.
dc.contributor.authorTurhan V.
dc.contributor.authorApiliogullari B.
dc.contributor.authorYilmaz H.
dc.contributor.authorBalasar M.
dc.date.accessioned2020-03-26T17:29:12Z
dc.date.available2020-03-26T17:29:12Z
dc.date.issued2008
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground and objective: Diphenhydramine has local anaesthetic and antimicrobial activity and may be used to prevent intravenous propofol injection pain. We studied the effect of adding diphenhydramine to propofol emulsions for preventing bacterial growth. Methods: Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli and Candida albicans cultures were inoculated into the following solutions: 1% propofol, 0.05% diphenhydramine + 1% propofol, 0.1% diphenhydramine + 1% propofol, 0.2% diphenhydramine + 1% propofol, 0.3% diphenhydramine + 1% propofol, 1% diphenhydramine and 0.1% lidocaine + 1% propofol. A 100-?L of inoculum suspension adjusted for each of the micro-organisms was added separately to each tube and left at 20°C. A 10-?L aliquot of each mixture was inoculated onto blood agar medium at 5 and 24 h. These plates were incubated at 35°C for 24 h. Each plated medium was read, and the number of colony-forming units were counted and recorded (n = 2). Analysis of variance (ANOVA) with a post hoc Tukey HSD test and paired t-tests were used for data analysis. P < 0.05 was considered as significant. Results: Diphenhydramine inhibited bacterial growth in propofol solutions in a dose-dependent manner. It was more effective than 0.1% lidocaine at similar concentrations in preventing bacterial growth for all organisms. Conclusion: Diphenhydramine had a significant inhibitory effect on bacterial growth in propofol. © 2008 Copyright European Society of Anaesthesiology.en_US
dc.identifier.doi10.1017/S0265021508004377en_US
dc.identifier.endpage740en_US
dc.identifier.issn0265-0215en_US
dc.identifier.issue9en_US
dc.identifier.pmid18471340en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage737en_US
dc.identifier.urihttps://dx.doi.org/10.1017/S0265021508004377
dc.identifier.urihttps://hdl.handle.net/20.500.12395/22929
dc.identifier.volume25en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofEuropean Journal of Anaesthesiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectDiphenhydramineen_US
dc.subjectDrug contamination, bacterialen_US
dc.subjectInfection postoperativeen_US
dc.subjectLidocaineen_US
dc.subjectPropofolen_US
dc.titleThe preventive effect of diphenhydramine on bacterial growth in propofol: A laboratory studyen_US
dc.typeArticleen_US

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