In vitro biological propensities and chemical profiling of Euphorbia milii Des Moul (Euphorbiaceae): A novel source for bioactive agents

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dc.contributor.authorSaleem, Hammad
dc.contributor.authorZengin, Gökhan
dc.contributor.authorLocatelli, Marcello
dc.contributor.authorMollica, Adriano
dc.contributor.authorAhmad, Irshad
dc.contributor.authorMahomoodally, Mohamad Fawzi
dc.contributor.authorAbidin, Syafiq Asnawi Zainal
dc.contributor.authorAhemad, Nafees
dc.date.accessioned2020-03-26T20:14:40Z
dc.date.available2020-03-26T20:14:40Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Fen Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractThe plants of Euphorbia genus have been extensively studied for their nutritive and therapeutic purposes. The present research is the foremost effort to investigate and compare the biological activities and chemical composition of dichloromethane (DCM) and methanol (MeOH) solvent extracts of Euphorbia milii Des Moul aerial and root parts. Antioxidant potential was determined using six different (FRAP, CUPRAC, Phosphomolybdenum, DPPH, ABTS and ferrous chelation) methods. The enzyme inhibition effects of the tested extracts were evaluated against acetylcholinesterase (AChE), butyrylcholinesterase (BChE), alpha-glucosidase, alpha-amylase and tyrosinase. Similarly, the amount of total phenolic and flavonoid contents were assessed via spectrophotometric methods and individual secondary metabolites were also determined using UHPLC-MS analysis. Methanolic extracts from both aerial and root parts contained the highest contents for phenolic and flavonoids which tends to correlate with their significant DPPH, ABTS (radical scavenging), FRAP, CUPRAC (reducing power) and alpha-glucosidase inhibition potentials. While, both the DCM extracts containing the lowest bioactive contents were most active in the phosphomolybdenum assay, cholinesterases and tyrosinase inhibition. The root extracts proved to be a better source of bioactive antioxidant molecules. Additionally, UHPLC-MS profiling of both the methanolic extracts revealed the presence of total 16 secondary metabolites belonging to five major groups (phenolic, flavonoid, coumarin, glycoside and alkaloid). To conclude, our results suggest that E. milii can be considered as a promising lead origin for natural bioactive enzyme inhibitory and antioxidant compounds which could pave the way for industrial applications.en_US
dc.identifier.citationSaleem, H., Zengin, G., Locatelli, M., Mollica, A., Ahmad, I., Mahomoodally, M. F. M., Abidin, S. A. Z., Ahemad, N. (2019). In Vitro Biological Propensities and Chemical Profiling of Euphorbia milii Des Moul (Euphorbiaceae): A Novel Source for Bioactive Agents. Industrial Crops & Products, 130, 9-15.
dc.identifier.doi10.1016/j.indcrop.2018.12.062en_US
dc.identifier.endpage15en_US
dc.identifier.issn0926-6690en_US
dc.identifier.issn1872-633Xen_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage9en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.indcrop.2018.12.062
dc.identifier.urihttps://hdl.handle.net/20.500.12395/37917
dc.identifier.volume130en_US
dc.identifier.wosWOS:000458942600002en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorZengin, Gökhan
dc.language.isoenen_US
dc.publisherELSEVIERen_US
dc.relation.ispartofINDUSTRIAL CROPS AND PRODUCTSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectEuphorbia miliien_US
dc.subjectPhytochemicalsen_US
dc.subjectAntioxidanten_US
dc.subjectEnzyme inhibitionen_US
dc.subjectTyrosinaseen_US
dc.titleIn vitro biological propensities and chemical profiling of Euphorbia milii Des Moul (Euphorbiaceae): A novel source for bioactive agentsen_US
dc.typeArticleen_US

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