Pharmacokinetics of danofloxacin in rainbow trout after different routes of administration

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dc.contributor.authorTerzi E.
dc.contributor.authorCorum O.
dc.contributor.authorBilen S.
dc.contributor.authorKenanoglu O.N.
dc.contributor.authorAtik O.
dc.contributor.authorUney K.
dc.date.accessioned2020-03-26T20:20:53Z
dc.date.available2020-03-26T20:20:53Z
dc.date.issued2020
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe pharmacokinetics of danofloxacin was studied in rainbow trout (Oncorhynchus mykiss) after single administration by intravenous (IV), intramuscular (IM) and oral (OR) gavage at a dose of 10 mg/kg and by 10 mg/L bath for 2 h at 11.7 ± 0.8 °C. Furthermore, minimal inhibitory concentrations (MICs) of danofloxacin against a pathogenic strain of Yersinia ruckeri, Pseudomonas spp., and Aeromonas hydrophila were determined. Plasma concentrations of danofloxacin were determined using high-performance liquid chromatograph - UV and further subjected to noncompartmental analysis. Elimination half-lives for IV, IM, OR and bath administration were 25.97 h, 42.43 h, 41.04 h and 40.41 h, respectively. Peak plasma concentrations (Cmax) for IM, OR and bath administration were 3.64 ± 0.12, 2.93 ± 0.23, and 0.36 ± 0.02 ?g/mL, respectively. Bioavailability was 105.87% (IM), 96.92% (OR) and 10.09% (bath). MIC values were 0.02 ?g/mL for Y. ruckeri, 3.2 ?g/mL for Pseudomonas spp., and 8 ?g/mL for A. hydrophila at 12 °C. Danofloxacin provides the desired AUC0 – 24/MIC (?125) and Cmax/MIC (?10) values for Y. ruckeri following administration at a dose of 10 mg/kg (L) from all routes administration, whereas inadequate for Pseudomonas spp. and A. hydrophila. This information may help in the use of danofloxacin in rainbow trout, but increasing doses pharmacokinetics with the residue depletion study and clinical studies in infected fish are needed. © 2020 Elsevier B.V.en_US
dc.description.sponsorshipKU-BAP01/2018–58en_US
dc.description.sponsorshipThis study was supported by The Coordination of Scientific Research Projects, University of Kastamonu (Project No: KU-BAP01/2018–58 ).en_US
dc.identifier.doi10.1016/j.aquaculture.2020.734984en_US
dc.identifier.issn0044-8486en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.aquaculture.2020.734984
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38691
dc.identifier.volume520en_US
dc.identifier.wosWOS:000515498200075en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofAquacultureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectDanofloxacinen_US
dc.subjectPharmacodynamicsen_US
dc.subjectPharmacokineticsen_US
dc.subjectRainbow trouten_US
dc.titlePharmacokinetics of danofloxacin in rainbow trout after different routes of administrationen_US
dc.typeArticleen_US

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