LC-MS quantification of parthenolide and cholinesterase inhibitory potential of selected Tanacetum L. (Emend. Briq.) taxa

Basit Öğe Kaydı
dc.contributor.authorOrhan, Ilkay Erdogan
dc.contributor.authorTosun, Fatma
dc.contributor.authorGulpinar, Ali Rifat
dc.contributor.authorKartal, Murat
dc.contributor.authorDuran, Ahmet
dc.contributor.authorMihoglugil, Feyyaz
dc.contributor.authorAkalgan, Demet
dc.date.accessioned2020-03-26T19:06:16Z
dc.date.available2020-03-26T19:06:16Z
dc.date.issued2015
dc.departmentSelçuk Üniversitesien_US
dc.description9th International Symposium on Chromatography of Natural Products (ISCNP) -- MAY, 2014 -- Lublin, POLANDen_US
dc.description.abstractThe acetonitrile extracts of various Tanacetum L. (Emend. Briq.) taxa from Turkey as well as parthenolide, a sesquiterpene lactone found in Tanacetum species as active substance were investigated for their inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), the key enzymes in pathogenesis of Alzheimer's disease, at 100 mu g mL(-1) using ELISA microplate assay. Most of the extracts displayed a remarkable AChE inhibition where the leaf of Tanacetum argenteum subsp. flabellifolium had the highest inhibition (96.68 +/- 0.35%). The extracts had moderate inhibition toward BChE, among which the stem of Tanacetum argyrophyllum var. argyrophyllum-1 exerted the best inhibition (63.81 +/- 3.64%). However, parthenolide exhibited low inhibition against both of the enzymes. Total flavonoid content of the extracts was determined spectrophotometrically. Parthenolide, a sesquiterpene lactone, was quantified in these taxa by LC-MS and the leaf of T. argenteum subsp. argenteum possessed the richest parthenolide amount (2.261 +/- 0.002%), while most of the species screened were found to contain the required percentage (0.2% minimum) by European Pharmacopeia. (C) 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipMedical Univ Lublinen_US
dc.identifier.doi10.1016/j.phytol.2014.10.003en_US
dc.identifier.endpage352en_US
dc.identifier.issn1874-3900en_US
dc.identifier.issn1876-7486en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage347en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.phytol.2014.10.003
dc.identifier.urihttps://hdl.handle.net/20.500.12395/32293
dc.identifier.volume11en_US
dc.identifier.wosWOS:000350569100064en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherELSEVIERen_US
dc.relation.ispartofPHYTOCHEMISTRY LETTERSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectTanacetumen_US
dc.subjectParthenolideen_US
dc.subjectAcetylcholinesteraseen_US
dc.subjectButyrylcholinesteraseen_US
dc.subjectAlzheimer's diseaseen_US
dc.titleLC-MS quantification of parthenolide and cholinesterase inhibitory potential of selected Tanacetum L. (Emend. Briq.) taxaen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu