Significance of Catechol-o-Methyltransferase Gene Polymorphism in Myofacial Pain Syndrome

Basit Öğe Kaydı
dc.contributor.authorErdal, M. E.
dc.contributor.authorHerken, H.
dc.contributor.authorMutlu, M. N.
dc.contributor.authorBayazit, Y. A.
dc.date.accessioned2020-03-26T16:46:04Z
dc.date.available2020-03-26T16:46:04Z
dc.date.issued2003
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe objective was to investigate possible association of the catechol o-methyl transferase (COMT) gene polymorphisms with myofacial pain syndrome (MFPS). The polymorphism of the COMT gene was compared between 49 patients with MFPS and 113 control subjects. Relationship between COMT polymorphism and psychiatric status of the patients was also assessed using SCL-90-R, BDS, and STAI-I and II tests. A PCR-based restriction fragment length polymorphism assay was used to detect G A transition at position 1947 in COMT. There was no relationship between MFPS and COMT polymorphism (p > 0.05). The patients who had MFPS without any temporomandibular joint problem had significantly higher expression of LL genotype when compared to those with joint problems (p < 0.05). There was no relationship between nocturnal bruxism and COMT polymorphism (p > 0.05). In conclusion, MFPS is not related to COMT polymorphism. COMT polymorphism is not associated with the psychiatric status of the patients. COMT polymorphism may be important for dose adjustment when the use of catechol drugs is anticipated.en_US
dc.identifier.citationErdal, M. E., Herken, H., Mutlu, M. N., Bayazit, Y. A., (2003). Significance of Catechol-o-Methyltransferase Gene Polymorphism in Myofacial Pain Syndrome. Pain Clinic, 15(3), 309-313. Doi: 10.1163/156856903767650844
dc.identifier.doi10.1163/156856903767650844en_US
dc.identifier.endpage313en_US
dc.identifier.issn0169-1112en_US
dc.identifier.issue3en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage309en_US
dc.identifier.urihttps://dx.doi.org/10.1163/156856903767650844
dc.identifier.urihttps://hdl.handle.net/20.500.12395/18560
dc.identifier.volume15en_US
dc.identifier.wosWOS:000185739800015en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherVSP BVen_US
dc.relation.ispartofPain Clinicen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCatechol-O-methyltransferaseen_US
dc.subjectMyofacial pain syndromeen_US
dc.subjectTemporomandibular joint disordersen_US
dc.titleSignificance of Catechol-o-Methyltransferase Gene Polymorphism in Myofacial Pain Syndromeen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu