Effects on the Clinical Indices and Gingival Crevicular Fluid Enzyme Activities of the Cyclical Regimen of Low-Dose Doxycycline Therapy for Adult Periodontitis.

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dc.contributor.authorAlptekin, Nilgün Özlem
dc.contributor.authorKurtoğlu, Firuze
dc.contributor.authorSerpek, Behiç
dc.contributor.authorDuran, I.
dc.contributor.authorGözlü, M.
dc.date.accessioned2020-03-26T16:36:26Z
dc.date.available2020-03-26T16:36:26Z
dc.date.issued2000
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe purpose of this study was to determine the effect of cyclic regimen of low dose doxycycline (20 mg) or placebo therapy following scaling and root planing on clinical parameters and crevicular fluid alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase and elastase activities. Fifteen adults (13 males, 2 females) with moderate to advanced adult periodontitis were recruited for the study. The LDD-treated group (n = 8 subjects) self administered low dose doxycycline b.i.d. (20 mg, p.o.) from time (treatment) to 2 months and then no drug from 2 to 4 months and finally low-dose doxycycline b.i.d. from 4 to 6 months (i.e. "cyclical" regimen). The placebo-treated group (n = 7 subjects) was asked to take placebo capsules (containing inactive filler; i.e. starchflour) b.i.d. according to the same "cyclical" regimen. No differences were found between LDD- and placebo-treated groups regarding any of the clinical parameters and gingival crevicular fluid enzyme activities. The relative attachment gain was significantly improved in both groups. The "cyclical" regimen of low-dose doxycycline was not found to reduce alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase and elastase activities in gingival crevicular fluid of the adult periodontitis patients over a 6-month time period.en_US
dc.identifier.citationAlptekin, N. O., Kurtoğlu, F., ,Serpek, B., Duran, I., Gözlü, M., (2000). Effects on the Clinical Indices and Gingival Crevicular Fluid Enzyme Activities of the Cyclical Regimen of Low-Dose Doxycycline Therapy for Adult Periodontitis. Journal of the International Academy of Periodontology, 2(1), 3-8.
dc.identifier.endpage8en_US
dc.identifier.issn1466-2094en_US
dc.identifier.issue1en_US
dc.identifier.pmid2003048280en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage3en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/17303
dc.identifier.volume2en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAlptekin, N. O.
dc.institutionauthorKurtoğlu, F.
dc.institutionauthorSerpek, B.
dc.institutionauthorDuran, I.
dc.institutionauthorGözlü, M.
dc.language.isoenen_US
dc.relation.ispartofJournal of the International Academy of Periodontologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleEffects on the Clinical Indices and Gingival Crevicular Fluid Enzyme Activities of the Cyclical Regimen of Low-Dose Doxycycline Therapy for Adult Periodontitis.en_US
dc.typeArticleen_US

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