Effects of magnesium sulfate on Na+,K+-ATPase and intracranial pressure level after cerebral ischemia

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dc.contributor.authorUstun, ME
dc.contributor.authorBariskaner, H
dc.contributor.authorYosunkaya, A
dc.contributor.authorGurbilek, M
dc.contributor.authorDogan, N
dc.date.accessioned2020-03-26T16:48:27Z
dc.date.available2020-03-26T16:48:27Z
dc.date.issued2004
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIn the present study, the effects of magnesium sulfate on Na+,K+-ATPase levels and intracranial pressure (ICP) after cerebral ischemia in rabbits were studied. Thirty New Zealand rabbits were divided into three groups. Group I was the control group. In group 2 (untreated group) cerebral ischemia was produced by clamping bilateral common carotid arteries for 60 min but in group 3 magnesium sulfate was administered 100 mg/kg i.v. 10 min after opening the clamps. In group 1, ICP recordings were obtained 5, 60 and 120 min after craniectomy. In groups 2 and 3, ICP recordings were obtained 5 min after craniectomy but before clamping, 60 min after clamping and 60 min after opening the clamps. After taking ICP recordings, brain cortices were resected and Na+,K+-ATPase activity was determined by subtracting the enzyme activity in the presence of ouabain from the total activity in the absence of ouabain method. There was a significant difference between Na+,K+-ATPase levels of ;group 1 and group 2 (P < 0.05). There was no significant difference in Na+,K+-ATPase levels between group 1 and 3 (P > 0.05), also preischemic ICP values were same in all groups (P > 0.05). Preischemic and postischemic ICP values were significantly different between groups 1 and 2 (P < 0.05), also postischemic (120 min) ICP values were significantly different between group 2 and group 3 (P < 0.05). ICP values correlate well with Na+,K+-ATPase level. These results demonstrate that cerebral ischemia leads to a decrease of ATPase level in the brain and magnesium sulfate suppresses the decrease of Na+,K+-ATPase, also magnesium sulfate treatment improves the ICP changes.en_US
dc.identifier.endpage175en_US
dc.identifier.issn0953-1424en_US
dc.identifier.issn1952-4021en_US
dc.identifier.issue3en_US
dc.identifier.pmid15724864en_US
dc.identifier.startpage169en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/19037
dc.identifier.volume17en_US
dc.identifier.wosWOS:000225370900003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherJOHN LIBBEY EUROTEXT LTDen_US
dc.relation.ispartofMAGNESIUM RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectmagnesium sulfateen_US
dc.subjectcerebral ischemiaen_US
dc.subjectNa+-K+-ATPaseen_US
dc.subjectrabbiten_US
dc.titleEffects of magnesium sulfate on Na+,K+-ATPase and intracranial pressure level after cerebral ischemiaen_US
dc.typeArticleen_US

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