Evaluation of the antiviral activity of Ballota glandulosissima hub.-mor. & patzak extracts against respiratory syncytial virus (RSV)
Yükleniyor...
Tarih
2019
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
TRAKYA UNIV BALKAN YERLESESI ENSTITULER BINASI
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
In order to find new and effective antiviral agents from natural sources, the antiviral properties of methanol and aqueous extracts of Ballota glandulosissima Hub.-Mor. & Patzak were evaluated by Colorimetric XTT test against Respiratory syncytial virus (RSV). The concentration required to provide 50% protection against cytopathic effects caused by the virus was defined as EC50, the selectivity index (SI) was determined from the ratio of CC50 (50 % Cytotoxic concentration) to EC50. The results showed that both the methanol (EC50 = 12.45 mu g/mL; SI = 24.84) and aqueous extracts (EC50 = 19.12 mu g/mL; SI = 24.59) of B. glandulosissima had almost the same strong anti-RSV activity as well as ribavirin, used as a positive control against RSV (EC50 = 3.25 mu g/mL, SI = 34.89). In conclusion, we can say that B. glandulosissima extracts are worthy of further studies in order to develop an alternative to the drugs used in clinical practice against RSV. This is the first report on the antiRSV activity of B. glandulosissima.
Açıklama
Anahtar Kelimeler
Kaynak
TRAKYA UNIVERSITY JOURNAL OF NATURAL SCIENCES
WoS Q Değeri
N/A
Scopus Q Değeri
Cilt
20
Sayı
2
Künye
Doğan, H. H., Duman, R. (2019). Evaluation of the Antiviral Activity of Ballota glandulosissima Hub.-Mor. & Patzak Extracts Against Respiratory Syncytial Virus (RSV). Trakya University Journal of Natural Sciences, 20(2), 121-127.
