Evaluation of the antiviral activity of Ballota glandulosissima hub.-mor. & patzak extracts against respiratory syncytial virus (RSV)

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dc.authorid0000-0001-8859-0188,
dc.contributor.authorDoğan, Hasan Hüseyin.
dc.contributor.authorDuman, Rüstem.
dc.date.accessioned2020-03-26T20:14:05Z
dc.date.available2020-03-26T20:14:05Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Fen Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractIn order to find new and effective antiviral agents from natural sources, the antiviral properties of methanol and aqueous extracts of Ballota glandulosissima Hub.-Mor. & Patzak were evaluated by Colorimetric XTT test against Respiratory syncytial virus (RSV). The concentration required to provide 50% protection against cytopathic effects caused by the virus was defined as EC50, the selectivity index (SI) was determined from the ratio of CC50 (50 % Cytotoxic concentration) to EC50. The results showed that both the methanol (EC50 = 12.45 mu g/mL; SI = 24.84) and aqueous extracts (EC50 = 19.12 mu g/mL; SI = 24.59) of B. glandulosissima had almost the same strong anti-RSV activity as well as ribavirin, used as a positive control against RSV (EC50 = 3.25 mu g/mL, SI = 34.89). In conclusion, we can say that B. glandulosissima extracts are worthy of further studies in order to develop an alternative to the drugs used in clinical practice against RSV. This is the first report on the antiRSV activity of B. glandulosissima.en_US
dc.description.sponsorshipSelcuk University, Scientific Research Projects Coordinating OfficeSelcuk University [SU-BAP-16401077]en_US
dc.description.sponsorshipThe authors would like to thank Selcuk University, Scientific Research Projects Coordinating Office (SU-BAP-16401077).en_US
dc.identifier.citationDoğan, H. H., Duman, R. (2019). Evaluation of the Antiviral Activity of Ballota glandulosissima Hub.-Mor. & Patzak Extracts Against Respiratory Syncytial Virus (RSV). Trakya University Journal of Natural Sciences, 20(2), 121-127.
dc.identifier.doi10.23902/trkjnat.543382en_US
dc.identifier.endpage127en_US
dc.identifier.issn2147-0294en_US
dc.identifier.issn2528-9691en_US
dc.identifier.issue2en_US
dc.identifier.pmid#YOKen_US
dc.identifier.startpage121en_US
dc.identifier.urihttps://dx.doi.org/10.23902/trkjnat.543382
dc.identifier.urihttps://hdl.handle.net/20.500.12395/37818
dc.identifier.volume20en_US
dc.identifier.wosWOS:000490570900006en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.institutionauthorDoğan, Hasan Hüseyin.
dc.institutionauthorDuman, Rüstem.
dc.language.isoenen_US
dc.publisherTRAKYA UNIV BALKAN YERLESESI ENSTITULER BINASIen_US
dc.relation.ispartofTRAKYA UNIVERSITY JOURNAL OF NATURAL SCIENCESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleEvaluation of the antiviral activity of Ballota glandulosissima hub.-mor. & patzak extracts against respiratory syncytial virus (RSV)en_US
dc.typeArticleen_US

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