Effects of flunixin meglumine and dexamethasone on metalloproteinases in canine keratoconjunctivitis

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dc.contributor.authorArıcan, Mustafa
dc.contributor.authorAlkan, Fahrettin
dc.contributor.authorAvkı, Sırrı
dc.date.accessioned2020-03-26T16:48:26Z
dc.date.available2020-03-26T16:48:26Z
dc.date.issued2004
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractTo determine the effects of subconjunctivally injected flunixin meglumine (a nonsteroidal anti-inflammatory drug) and dexamethasone on matrix metalloproteinases (MMPs) in the tears of dogs with traumatic keratoconjunctivitis, six dogs with experimental keratoconjunctivitis were used. A 1 cm incision was made in the corneal epithelium. Tear samples from each dog were collected prior to and one week after surgery under sterile condition. The dogs (group 1) were treated with 1 mg /kg of subconjunctival flunixin meglumine (50 mg/mL)The dogs (group 2) were treated with 0.5 mg/kg of subconjunctival dexamethasone (8 mg/mL). Gelatine zymography was performed to determine enzyme activities in control and traumatic keratoconjunctivitis tear samples. Matrix metalloproteinases are present in tears of both normal and diseased eyes. All enzyme bands were totaly inhibited by dexamethasone and only active MMP-9 partially inhibited by flunixin meglumine. Effect of flunixin meglumine and dexamethasone give insight into the treatment procedure and pathogenesis of these diseases and may provide useful information for other species, particularly man.en_US
dc.identifier.endpage546en_US
dc.identifier.issn0035-1555en_US
dc.identifier.issn2258-0646en_US
dc.identifier.issue11en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage543en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/19034
dc.identifier.volume155en_US
dc.identifier.wosWOS:000226041000005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherECOLE NATIONALE VETERINAIRE TOULOUSEen_US
dc.relation.ispartofREVUE DE MEDECINE VETERINAIREen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectcanineen_US
dc.subjectmetalloproteinasesen_US
dc.subjectkeratitisen_US
dc.subjectflunixin meglumineen_US
dc.subjectdexamethasoneen_US
dc.titleEffects of flunixin meglumine and dexamethasone on metalloproteinases in canine keratoconjunctivitisen_US
dc.typeArticleen_US

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