Epidural Administration of Midasolam for Chronic Central Pain and Spasticity in Spinal Cord Injured Patients
Küçük Resim Yok
Tarih
1997
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In the patients with spinal cord injury (SCI) chronic pain and spasticity affect significantly both the efficacy of rehabilitation and the quality of life. Recently it was shown that intrathecally and epidurally administered midasolam has analgesic and antispatic effects in both animals and humans so that it constitutes an alternative to be used in patients with SCI. In this study, four paraplegics who suffered from chronic central pain and spasticity in their lower extremities were given midasolan 6 times daily (dose 40 ?g/kg dose dissolved in 10 ml normal saline) via lumbar epidural catheter using pain management provider. Spasticity was monitored by means of a modified Ashwort scale, and pain evaluation was performed by face scale and VAS. The patients were hospitalized at least for two weeks and were observed for the efficacy of the drug. Although epidural administration of midasolam relieved both central pain and spasticity, it's efficacy on central pain was more pronounced. There were no significant side effects is any patient. We propose that midasolam may be given by epidural catheter or implantable drug pump for the treatment of central pain and/or spinal spasticity in spinal cord injured patients.
Açıklama
Anahtar Kelimeler
Central pain, Midasolam, Spasticity, Spinal cord injuries
Kaynak
Journal of Rheumatology and Medical Rehabilitation
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
8
Sayı
4
Künye
Özerbil, O. M., Duman, A., Yosunkaya, A., Bayram, A., Üstün, M. E., (1997). Epidural Administration of Midasolam for Chronic Central Pain and Spasticity in Spinal Cord Injured Patients. Journal of Rheumatology and Medical Rehabilitation, 8(4), 328-330.
