Role of Tumor Necrosis Factor Alpha Promoter Polymorphisms in Interferon Related Side Effects in Chronic Hepatitis B Patients Under Interferon Alpha 2b Treatment
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Dosyalar
Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: Interferon alpha therapy is associated with series of adverse ef-fects leading premature discontinuation of treatment. Here we aimed to de-termine the effects of Tumor necrosis alpha promoter polymorphisms on in-terferon related side effects during interferon alpha 2b treatment in chron-ic hepatitis B patients.Material and Methods: This observational study enrolled 50 chronic hepati-tis B patients, who were treated with interferon alpha 2b 10 tiw plus lamivu-dine 100mg/day at Selçuk University Meram Medical Faculty Department of Infectious Diseases and Clinical Bacteriology between 2006-2007. Patients were followed-up with complete blood count, transaminases and amylase monthly at out patient clinics of our department. All patients were asked to fill a questionnaire to evaluate the interferon related side effects at every vis-it. Tumor necrosis factor alpha -238 and -308 polymorphisms were investi-gated with PCR-Restriction fragment length polymorphisms.Results: Arthralgia was present in 93.8% of patients. Exhaustion, loss of ap-petite, mount dryness and fever are the leading complaints of the patients. Median complaint scores were 9, 9.5, 11 and 5 at 4th, 12th, 24th and 48th week visits, respectively. Thrombocytopenia and leucopenia were detected in 8 (16%) and 5 (10%) patients, respectively. One-third of the patients report-ed depressive mood however, depression was diagnosed in 5 (10%) patients. TNF alpha promoter 238GG and 308GG allele was present in 42/50 and 43/50 patients, respectively. No association was found between TNF pro-moter allele and certain patient-reported side effect, complaint score, hema-tological and psychological adverse effects. Conclusion: TNF alpha promoter polymorphisms do not contribute to oc-currence of IFN alpha treatment related side effects.
Açıklama
Anahtar Kelimeler
Acil Tıp, Adli Tıp, Alerji, Anatomi ve Morfoloji, Androloji, Anestezi, Biyofizik, Biyokimya ve Moleküler Biyoloji, Biyoloji, Biyoteknoloji ve Uygulamalı Mikrobiyoloji, Cerrahi, Dermatoloji, Endokrinoloji ve Metabolizma, Enfeksiyon Hastalıkları, Fizyoloji, Gastroenteroloji ve Hepatoloji, Genel ve Dahili Tıp, Geriatri ve Gerontoloji, Göz Hastalıkları, Halk ve Çevre Sağlığı, Hematoloji, Hücre Biyolojisi, İmmünoloji, Kadın Hastalıkları ve Doğum, Kalp ve Kalp Damar Sistemi, Klinik Nöroloji, Kulak, Burun, Boğaz, Mikrobiyoloji, Nörolojik Bilimler, Odyoloji ve Konuşma-Dil Patolojisi, Onkoloji, Ortopedi, Patoloji, Pediatri, Periferik Damar Hastalıkları, Psikiyatri, Radyoloji, Nükleer Tıp, Tıbbi Görüntüleme, Rehabilitasyon, Romatoloji, Sağlık Bilimleri ve Hizmetleri, Solunum Sistemi, Spor Bilimleri, Tamamlayıcı ve Entegre Tıp, Temel Sağlık Hizmetleri, Tıbbi Araştırmalar Deneysel, Tıbbi Etik, Tıbbi İnformatik, Tıbbi Laboratuar Teknolojisi, Transplantasyon, Tropik Tıp, Üroloji ve Nefroloji, Yoğun Bakım, Tıp
Kaynak
Acta Medica
WoS Q Değeri
Scopus Q Değeri
Cilt
50
Sayı
2
Künye
İnkaya A. Ç., Arıbaş E. T., Kandemir B., Acar H., Bitirgen M. (2019). Role of Tumor Necrosis Factor Alpha Promoter Polymorphisms in Interferon Related Side Effects in Chronic Hepatitis B Patients Under Interferon Alpha 2b Treatment. Acta Medica, 50(2), 32-38.
